文献类型：期刊文献

英文题名：Mussel-Inspired Thermoresponsive Polypeptide-Pluronic Copolymers for Versatile Surgical Adhesives and Hemostasis

作者：Lu, Dedai[1];Wang, Hongsen[1];Li, Ting'e[1];Li, Yunfei[1];Dou, Fajuan[1];Sun, Shaobo[2];Guo, Hongyun[3];Liao, Shiqi[3];Yang, Zhiwang[1];Wei, Qiangbing[1];Lei, Ziqiang[1]

第一作者：Lu, Dedai

通信作者：Lu, DD[1]

机构：[1]Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Polymer Mat Gansu Prov, Key Lab Ecoenvironm Related Polymer Mat,Minist Ed, Lanzhou 730070, Peoples R China;[2]Gansu Univ Chinese Med, Sch Basic Med Sci, Lanzhou 730000, Peoples R China;[3]Gansu Prov Canc Hosp, Inst Gansu Med Sci Res, Lanzhou 730050, Peoples R China

第一机构：Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Polymer Mat Gansu Prov, Key Lab Ecoenvironm Related Polymer Mat,Minist Ed, Lanzhou 730070, Peoples R China

通信机构：[1]corresponding author), Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Polymer Mat Gansu Prov, Key Lab Ecoenvironm Related Polymer Mat,Minist Ed, Lanzhou 730070, Peoples R China.

年份：2017

卷号：9

期号：20

起止页码：16757

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20172203709614);Scopus(收录号：2-s2.0-85019660006);WOS:【SCI-EXPANDED(收录号:WOS:000402498600005)】；

基金：This work was supported in part by the National Natural Science Foundation of China (nos. 51103118, 21504070), the Research Project of Universities of Gansu Province (2015A-005), Innovation Team Basic Scientific Research Project of Gansu Province (1606RJIA324), and Innovation Team Project of NWNU. We also thank Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education and Key Lab of Polymer Materials of Gansu Province for financial support.

语种：英文

外文关键词：polypeptide; thermoresponsive; mussel-inspired; biocompatible; surgical adhesive

摘要：Inspired by marine mussel adhesive proteins, polymers with catechol side groups have been extensively explored in industrial and academic research. Here, Pluronic L-31 alcoholate ions were used as the initiator to prepare a series of polypeptide Pluronic polypeptide triblock copolymers via ring-opening polymerization of L-DOPA-N-carboxyanhydride (DOPA-NCA), L-arginine-NCA (Arg-NCA), L-cysteine-NCA (CysNCA), and epsilon-N-acryloyl lysine-NCA (Ac-Lys-NCA). These copolymers demonstrated good biodegradability, biocompatibility, and thermoresponsive properties. Adhesion tests using porcine skin and bone as adherends demonstrated lap-shear adhesion strengths up to 106 kPa and tensile adhesion strengths up to 675 kPa. The antibleeding activity and tissue adhesive ability were evaluated using a rat model. These polypeptide Pluronic copolymer glues showed superior hemostatic properties and superior effects in wound healing and osteotomy gaps. Complete healing of skin incisions and remodeling of osteotomy gaps were observed in all rats after 14 and 60 days, respectively. These copolymers have potential uses as tissue adhesives, antibleeding, and tissue engineering materials.