文献类型：期刊文献

英文题名：Food-derived protein-based calcium chelates: digestive stability, intestinal transport, and bone-related functions

作者：Li, Tingting[1];Gao, Yaxiong[2];Zhou, Qiang[2];Xie, Yuan[3];Xie, Xingwen[3];Wei, Wenjie[4]

第一作者：Li, Tingting

通信作者：Xie, XW[1];Wei, WJ[2]

机构：[1]Gansu Prov Matern & Child Hlth Hosp, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China;[3]Gansu Prov Hosp TCM, Lanzhou, Peoples R China;[4]Northwest Normal Univ, Lanzhou, Peoples R China

第一机构：Gansu Prov Matern & Child Hlth Hosp, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp TCM, Lanzhou, Peoples R China;[2]corresponding author), Northwest Normal Univ, Lanzhou, Peoples R China.

年份：2026

卷号：13

外文期刊名：FRONTIERS IN NUTRITION

收录：;Scopus(收录号：2-s2.0-105048633371);WOS:【SCI-EXPANDED(收录号:WOS:001860534900001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. National Natural Science Foundation of China (No. 82374491); National Natural Science Foundation of China (No. 82160918 and 82160911); Special Project of the Central Government for Guiding Local Science and Technology Development-Innovation Platform for Enhancing the Prevention and Control Capacity of Common Diseases in Gansu Province (YDZX20206200002356); and Lanzhou Science and Technology Development Guiding Program (No. 2025-5-134), the Lanzhou Science and Technology Plan Project (No. 2022-5-862) and the Gansu Provincial Natural Science Foundation Project (No. 26JRRA724).

语种：英文

外文关键词：calcium bioaccessibility; gastrointestinal digestion; gut-bone axis; intestinal transport; osteoporosis; peptide-calcium chelates; protein-based calcium chelates

摘要：Conventional calcium supplements often show limited bioaccessibility and suboptimal gastrointestinal tolerance. Food-derived proteins, protein hydrolysates, and peptide-calcium chelates have been investigated as protein-based calcium chelates. This review organizes these systems along a structural continuum from proteins to hydrolysates and peptide-calcium chelates, in which enzymatic hydrolysis, fractionation, purification, and chelation reshape carrier composition, molecular weight distribution, and calcium coordination characteristics. Within this framework, this review examines the preparation strategies, molecular features, gastrointestinal stability, intestinal transport behavior, and bone-related functions of protein-based calcium chelates. Particular attention is given to the effects of chelate type, molecular weight distribution, peptide sequence, and coordination stability on calcium retention, solubility, and transport-related behavior during digestion, as well as their links with osteogenic responses, gut microbiota changes, and the gut-bone axis. Overall, this review provides a structured framework for evaluating food-derived protein-based calcium chelates and their potential application in food-based calcium delivery systems, while highlighting future needs in functional validation, product standardization, safety assessment, and clinically relevant evidence.