文献类型：期刊文献

英文题名：Pharmacological and non-pharmacological interventions for osteoporosis A protocol for an overview with an evidence map and a network meta-analysis of trials

作者：Tian, Jidong[1];Wu, Shuo[2];Dong, Lin[1];Tang, Hao[3]

第一作者：Tian, Jidong

通信作者：Wu, S[1]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Peoples Hosp Jiayuguan City 1, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), First Peoples Hosp Jiayuguan City, Jiayuguan, Gansu, Peoples R China.

年份：2021

卷号：100

期号：24

起止页码：e26429

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85108387230);WOS:【SCI-EXPANDED(收录号:WOS:000661624000068)】；

基金：This present study is supported by the Jiayuguan City Science and Technology Plan Project (Number: 2015Y-07).

语种：英文

外文关键词：A MeaSurement Tool to Assess systematic Reviews 2; Grading of Recommendations Assessment; Development and Evaluation; network meta-analysis; osteoporosis; overview

摘要：Background: Osteoporosis is a common bone disease that has a significant social and economic effect. Many meta-analyses of pharmacological and non-pharmacological treatments for osteoporosis have been reported, but the findings may be contradictory, and both the reporting and methodological quality remain unknown. As a result, an overview that includes a network meta-analysis was proposed to address these issues. Methods: The Cochrane library, PubMed, Embase, CBM, and CNKI databases will be systematically searched for meta-analyses of osteoporosis interventions from inception to May 2021. In order to evaluate the reporting and methodological quality of each included meta-analysis, Preferred Reporting Items for Systematic Review and Meta-analysis 2020 (PRISMA-2020), and A MeaSurement Tool to Assess systematic Reviews 2 (AMSTAR-2) will be used. For the assessment of the relative efficacy and safety of treatments reported in the randomized controlled trials included in the meta-analyses identified by the overview, a Bayesian network meta-analysis will be carried out. The odds ratio and standard mean difference with their 95% credible intervals will be used to present the binary and continuous outcomes, respectively, and the Grading of Recommendations Assessment, Development and Evaluation method will be used to determine the certainty of the evidence through Confidence In Network Meta-Analysis. Data analysis will be performed using WinBUGS, R, and Stata, with a 2-sided P Results: The findings of this overview, which includes a network meta-analysis, will be submitted to a peer-reviewed journal for publication. Conclusion: An overview with network meta-analysis will provide evidence on the efficacy and safety of pharmacological and non-pharmacological interventions for osteoporosis, while also identifying the flaws in previously published meta-analyses. All of these results may be used to improve clinical decision-making and future studies. INPLASY registration number: INPLASY202150022.