文献类型：期刊文献

中文题名：从氧化损伤标志物论述氧化应激与儿童孤独症谱系障碍

英文题名：Discussion on Oxidative Stress and Autism Spectrum Disorder Based on Oxidative Damage Markers

作者：崔润芝[1];史正刚[1];霍曼[1];赵志英[1];谈慧媛[1];尉苗苗[1];冯鹏[1];尚菁[1]

第一作者：崔润芝

机构：[1]甘肃中医药大学,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2022

卷号：39

期号：11

起止页码：40

中文期刊名：中医药信息

外文期刊名：Information on Traditional Chinese Medicine

基金：国家自然科学基金地区基金项目(81960886)。

语种：中文

中文关键词：儿童孤独症谱系障碍;氧化应激;氧化损伤标志物;中医药治疗

外文关键词：Autism spectrum disorder;Oxidative stress;Oxidative damage marker;TCM treatment

摘要：儿童孤独症谱系障碍(autismspectrumdisorder,ASD)是一种异质性的广泛性神经发育障碍,其特征是在交流、社会行为、兴趣和活动方面存在障碍。多项研究证明,氧化应激(oxidativestress,OS)与ASD密切相关,其可通过代谢产物等多种方式参与ASD的生理和病理过程。本文从丙二醛、F2-异前列腺素、乙酰-赖氨酸加合物、蛋白质羰基、二酪氨酸、8-羟基-脱氧鸟苷等OS标志物的改变以及中医药治疗ASD与OS之间的关系,阐述了ASD患儿体内氧化损伤产物的堆积及抗氧化代谢的紊乱,而中医药治疗ASD疗效明显,特别是针刺可调节OS,但其治疗机制未明,今后应以分子生物学和机体生化为切入点加大机制的研究。
Autism spectrum disorder(ASD)in children is a heterogeneous,pervasive neuro developmental disorder characterized by impairments in communication,social behavior,interests,and activities.Oxidative stress(OS),as a hot topic of discussion for many years,has been widely concerned by scholars.A number of studies have shown that OS is closely associated with ASD,and it can participate in physiological and pathological process of ASD through a variety of ways including metabolites.This study elaborated the accumulation of oxidative damage products and the disorder of antioxidant metabolism in children with ASD,from the perspectives of OS markers of MDA,F2-isoprolandin,HEL,protein carbonyl,IDT and 8-OHdG,as well as from the relationship between TCM treatment for ASD and OS.TCM therapies have significant therapeutic effects in treating ASD,for example,acupuncture can regulate OS,but the specific mechanism remains unclear.Researches on molecular biology and body biochemistry should be taken as the entry points for later studies in mechanism.