文献类型：期刊文献

中文题名：长链非编码RNA CYTOR在人类癌症中调控机制研究进展

英文题名：Research progress on regulatory mechanism of long non-coding RNA CYTOR in human cancer

作者：孙少康[1];伊琳[1];黄勇[1];刘晓燕[1];赵玉[1];龙凤[1,2,3]

第一作者：孙少康

机构：[1]甘肃中医药大学基础医学院;[2]甘肃省中医药防治慢性疾病重点实验室;[3]甘肃省高校重大疾病分子医学与中医药防治研究省级重点实验室,甘肃兰州730000

第一机构：甘肃中医药大学基础医学院（敦煌医学研究所）

年份：2023

卷号：39

期号：3

起止页码：419

中文期刊名：中国药理学通报

外文期刊名：Chinese Pharmacological Bulletin

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：甘肃省“双一流”科研重点项目(No GSSYLXM-05);甘肃省高等学校创新基金项目(No 2021A-078)。

语种：中文

中文关键词：长链非编码RNA;细胞骨架调节因子RNA;癌症;调控机制;调节因子;癌症相关信号通路;癌症临床特征

外文关键词：LncRNA;CYTOR;cancer;regulatory mechanism;regulators;cancer related signaling pathways;clinical features of cancer

摘要：癌症因其多具有异质性、耐药性以及易复发转移的特点,临床很难治愈。揭示癌症发生发展的分子机制、鉴定新的诊断标志物和分子治疗靶标,无疑是解决癌症早期诊断、治疗以及改善患者预后问题的有效策略。越来越多的研究表明,长链非编码RNA(long non-coding RNA,lncRNA)在人类癌症中特异性表达,是癌症发生发展的关键调节因子。细胞骨架调节因子RNA(cytoskeleton regulator RNA,CYTOR)是近年发现的一种致癌性lncRNA。CYTOR在多种类型癌症中均高表达,通过多种途径调控癌症发生发展,可能是癌症早期诊断、分子靶向治疗以及评估预后有效生物标志物。该文综述了CYTOR在人类癌症中的分子调控机制及其相关生物学效应,以期为临床癌症的诊疗提供新的科学参考。
Cancer is difficult to cure because of its heterogeneity,drug resistance and easy recurrence and metastasis.Revealing the molecular mechanism of cancer genesis and development,identifying new diagnostic markers and molecular therapeutic targets are undoubtedly effective strategies to solve the problems of early diagnosis,treatment and improvement of prognosis of cancer patients.More and more studies have shown that long non-coding RNA(lncRNA)is specifically expressed in human cancer and is a key regulator of cancer occurrence and development.Cytoskeleton regulator RNA(CYTOR)is a carcinogenic lncRNA found in recent years.CYTOR is highly expressed in many types of cancer and regulates the development of cancer through a variety of pathways,which may be an effective biomarker for early cancer diagnosis,molecular targeted therapy and prognosis assessment.This paper reviews the molecular regulatory mechanism and related biological characteristics of CYTOR in human cancer,in order to provide new scientific reference for clinical cancer diagnosis and treatment.