文献类型：期刊文献

英文题名：Advances in understanding effects of miRNAs on apoptosis, autophagy, and pyroptosis in knee osteoarthritis

作者：An, Fangyu[1];Sun, Bai[2];Liu, Ying[3];Wang, Chunmei[3];Wang, Xiaxia[2];Wang, Jiayu[2];Liu, Yongqi[3];Yan, Chunlu[2,4]

第一作者：安方玉

通信作者：Yan, CL[1];Liu, YQ[2];Yan, CL[3]

机构：[1]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Res Ctr Tradit Chinese Med Gansu, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Sch Basic Med, Lanzhou 730000, Gansu, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Res Ctr Tradit Chinese Med Gansu, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：298

期号：6

起止页码：1261

外文期刊名：MOLECULAR GENETICS AND GENOMICS

收录：;Scopus(收录号：2-s2.0-85175380302);WOS:【SCI-EXPANDED(收录号:WOS:001091518800001)】；

基金：This article was funded by the grants from Natural Science Program in Gansu Province (20JR5RA185), Scientific Research Program of Gansu Chinese Medicine Bureau (GZKP-2021-34), the Young Doctor Fund Program of Colleges and Universities in Gansu Province (2022QB-091), Innovation Fund Project of Higher Education Institutions in Gansu Provincial (2022A-072).

语种：英文

外文关键词：Knee osteoarthritis; Apoptosis; Autophagy; Pyroptosis; miRNA

摘要：MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs. MicroRNAs-mediated signaling pathways play a critical regulatory role in inducing apoptosis, autophagy, and pyroptosis in developing knee osteoarthritis (KOA). Given this, we searched databases, such as PubMed, using keywords including "miRNA," "knee osteoarthritis," "apoptosis," "autophagy," "pyroptosis", and their combinations. Through an extensive literature review, we conclude that miRNAs can be modulated through various signaling pathways, such as Wnt/beta-catenin, TGF-beta, PI3K/AKT/mTOR, and NLRP3/Caspase-1, to regulate apoptosis, autophagy, and pyroptosis in KOA. Furthermore, we note that P2X7R and HMGB1 may be crucial regulatory molecules involved in the interconnected regulation of apoptosis, autophagy, and pyroptosis in KOA. Additionally, we describe that miR-140-5p and miR-107 can modulate the advancement of KOA chondrocytes by targeting distinct molecules involved in apoptosis, autophagy, and pyroptosis, respectively. Therefore, we conclude that miRNAs may be potential biomarkers and therapeutic targets for the early prediction, diagnosis, and effective therapeutic approaches of KOA.