文献类型：期刊文献

英文题名：Immune drivers of venous thrombosis: orchestrating initiation, formation, and resolution within the hypoxic microenvironment

作者：Yin, Jiaojiao[1,2,3];Zhu, Enpeng[1];Zheng, Xiaojing[2];Ha, Xiaoqin[2];Li, Bing[2]

第一作者：尹晶晶;Yin, Jiaojiao

通信作者：Ha, X[1];Li, B[1]

机构：[1]Gansu Prov Matern & Child Care Hosp, Dept Clin Lab, Lanzhou, Gansu, Peoples R China;[2]940th Hosp Chinese Peoples Liberat Army Joint Supp, Dept Clin Lab, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China

第一机构：Gansu Prov Matern & Child Care Hosp, Dept Clin Lab, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), 940th Hosp Chinese Peoples Liberat Army Joint Supp, Dept Clin Lab, Lanzhou, Gansu, Peoples R China.

年份：2026

卷号：17

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001800523300001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by grant from the Natural Science Foundation of Gansu Province (25JRRA424), the Scientific Research Project of Gansu Provincial Health Commission (GSWSKY2025-67) and the Scientific Research Fund Project of Gansu Provincial Maternity and Child-care Hospital (GMCCH2024-3-9).

语种：英文

外文关键词：endothelial cell; hypoxic microenvironment; macrophage; monocyte; neutrophil; venous thrombosis

摘要：Venous thromboembolism (VTE) is a prevalent and life-threatening condition whose pathogenesis extends beyond a mere coagulation disorder to encompass a dynamic interplay with the immune system, a concept known as thromboinflammation. Hypoxia, a critical but often overlooked component of the venous microenvironment, serves as a master regulator that orchestrates immune cell responses throughout the thrombotic cascade-from initiation to resolution. This review synthesizes current evidence to establish an integrated framework linking the hypoxic microenvironment to immune-mediated venous thrombosis. We detail how hypoxia, arising from external exposure, pathological stasis, or intracellular metabolic reprogramming (pseudohypoxia), reprograms the function of key cellular players. This includes endothelial cell activation with glycocalyx shedding and adhesive molecule expression, neutrophil extracellular traps (NETs) formation, and monocyte recruitment. Collectively, these hypoxia-driven events create a prothrombotic milieu. Conversely, during the resolution phase, hypoxia-inducible factor (HIF)-1 alpha signaling promotes angiogenesis, while hypoxia-induced metabolic shifts-particularly lactate accumulation-appear to influence macrophage polarization towards a pro-resolving phenotype. By elucidating the central role of immune cells as effectors of hypoxic signaling, this review highlights the hypoxic-immune axis as a pivotal pathway in venous thrombosis and points to potential immunomodulatory strategies for future therapeutics.