文献类型：期刊文献

英文题名：Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis

作者：Huo, Xiaqin[1,2,3,4];Yao, Liang[3,4];Han, Xue[1];Li, Wen[1,2];Liu, Junjuan[1,2];Zhou, Lijun[1,2];Gou, Yuanfeng[1,2];Yang, Kehu[3,4];Liu, Huiling[1,2]

第一作者：Huo, Xiaqin

通信作者：Liu, HL[1];Liu, HL[2];Yang, KH[3];Yang, KH[4]

机构：[1]Gansu Prov Peoples Hosp, Dept Gynecol & Obstet, Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Dept Clin Med, Lanzhou 730000, Gansu, Peoples R China;[3]Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Prov Hosp, Inst Clin Res & Evidence Based Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：Gansu Prov Peoples Hosp, Dept Gynecol & Obstet, Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Peoples Hosp, Dept Gynecol & Obstet, Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Dept Clin Med, Lanzhou 730000, Gansu, Peoples R China;[3]corresponding author), Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[4]corresponding author), Gansu Prov Hosp, Inst Clin Res & Evidence Based Med, Lanzhou 730000, Gansu, Peoples R China.|[10735c1ddf597548aedb5]甘肃中医药大学临床医学院;[10735]甘肃中医药大学;

年份：2019

卷号：299

期号：3

起止页码：599

外文期刊名：ARCHIVES OF GYNECOLOGY AND OBSTETRICS

收录：;Scopus(收录号：2-s2.0-85059580868);WOS:【SCI-EXPANDED(收录号:WOS:000459760600001)】；

基金：This study was funded by the National Natural Science Foundation of China (Project No. 81560426) and the Research Project of Gansu Provincial People's Hospital in China (No. 16GSSY6-8).

语种：英文

外文关键词：Hysterectomy; Ovarian cancer; Risk; Meta-analysis

摘要：PurposeThe association between hysterectomy for benign gynecologic disease and ovarian cancer risk was controversial. Thus, we perform a systematic review and meta-analysis to evaluate the effect of hysterectomy and ovarian cancer risk.MethodsPubMed, Cochrane Library, and Embase were searched from 2000 toJanuary 2018. A random-effect model was used to obtain the summary odds risks (ORs) and 95% confidence intervals (CIs).ResultsA total of 18 case-control studies were included in the meta-analysis. We found that there was no statistical significance for ovarian cancer risk following hysterectomy (OR 0.97, 95% CI 0.83-1.12). And in subgroup analysis, the protective effects were observed for invasive endometrioid/clear cell carcinomas after hysterectomy (OR 0.70, 95% CI 0.51, 0.94; I-2=0%), and no statistical significance for serous and mucinous.ConclusionsHysterectomy showed no relationship with ovarian cancer. But a reduced risk was found for endometrioid-invasive OC. These findings could provide evidence for patients with benign gynecological disease and clinicians to make appropriate decision about whether to conduct hysterectomy.