文献类型：期刊文献

中文题名：Hippo-YAP/TAZ与Notch信号通路在肝纤维化中的作用

英文题名：The role of Hippo-YAP/TAZ and Notch signaling pathway in liver fibrosis

作者：王莉[1];赵秀萍[1];谢娇娇[1];何燕芳[1];郭才[1];郑兰兰[1];马燕花[1]

第一作者：王莉

机构：[1]甘肃中医药大学第一临床医学院,兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2023

卷号：43

期号：3

起止页码：402

中文期刊名：生命的化学

外文期刊名：Chemistry of Life

收录：CSTPCD

基金：国家自然科学基金地区基金项目(81860821);2019年甘肃省高等学校创新能力提升项目(2019B-104);甘肃中医药大学第一临床医学院2021年度研究生创新基金项目(LCCX2021001)。

语种：中文

中文关键词：Hippo-YAP/TAZ;Notch信号通路;肝纤维化

外文关键词：Hippo-YAP/TAZ;Notch signaling pathway;liver fibrosis

摘要：病毒性或代谢性慢性肝病引起的肝纤维化是全球健康的一大挑战。Hippo-YAP/TAZ通路与Notch信号通路在肝纤维化进展中发挥了至关重要的作用。经典的Hippo通路核心激酶级联在大量外界信号的作用下,通过磷酸化使转录共激活因子YAP/TAZ失活,从而调控细胞的生长与增殖以及干细胞再生、肿瘤形成等过程。Notch信号通路通过调控脂质代谢、IR、氧化应激、自噬、炎症与纤维化等方面参与肝病的发生与发展。该文就Hippo-YAP/TAZ与Notch信号通路在肝纤维化过程中对肝星状细胞、巨噬细胞、肝脂质代谢等方面的影响及两条通路的交互作用进行了详细地综述。概括了2条通路在肝纤维化中的研究现状,总结分析了交互作用研究中存在的问题和未来的方向,旨在为肝纤维化的防治提供新的靶点和理论依据。
Hepatic fibrosis caused by viral or metabolic chronic liver disease is a major global health challenge.Hippo-YAP/TAZ pathway and Notch signaling pathway play a crucial role in the progression of hepatic fibrosis.The classical core kinase cascade of Hippo pathway inactivates transcription coactivator YAP/TAZ through phosphorylation under the action of a large number of external signals,thus regulating cell growth and proliferation,stem cell regeneration,tumor formation and other processes.Notch signaling pathway is involved in the occurrence and development of liver disease by regulating lipid metabolism,IR,oxidative stress,autophagy,inflammation and fibrosis.In this paper,the effects of Hippo-YAP/TAZ and Notch signaling pathways on hepatic stele cells,macrophages,hepatic lipid metabolism and the interaction between the two pathways in the process of hepatic fibrosis were reviewed in detail.This paper not only summarizes the research status of the two pathways in hepatic fibrosis,but also summarizes and analyzes the existing problems and future directions in the study of interaction,aiming at providing new targets and theoretical basis for the prevention and treatment of hepatic fibrosis.