文献类型：期刊文献

英文题名：Single Test-Based Diagnosis and Subtyping of Pulmonary Hypertension Caused by Fibrosing Mediastinitis Using Plasma Metabolic Analysis

作者：Zhao, Yating[1,2,3];Ding, Chunmeng[4,5];Su, Hongling[3];Wang, Aqian[3];Tang, Aiping[6];Zhao, Hongfan[7];Ma, Ya[6];Zhang, Min[8];Liu, Wanshan[4,5];Wang, Ruimin[4,5];Zhang, Ziyue[4,5];Yang, Shouzhi[4,5];Liang, Dingyitai[4,5];Huang, Yida;Qian, Kun;Huang, Lin[9];Fu, Qihua[10];Cao, Yunshan[1]

第一作者：Zhao, Yating

通信作者：Cao, YS[1];Huang, L[2];Fu, QH[3]

机构：[1]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Heart Lung & Vessels Ctr, Chengdu 610072, Sichuan, Peoples R China;[2]Jiangsu Univ, Sch Med, Zhenjiang 212000, Peoples R China;[3]Gansu Prov Hosp, Pulm Vasc Dis Ctr PVDC, Dept Cardiol, Lanzhou 730000, Peoples R China;[4]Shanghai Jiao Tong Univ, Inst Med Robot, Sch Biomed Engn, State Key Lab Syst Med Canc, Shanghai 200030, Peoples R China;[5]Shanghai Jiao Tong Univ, Shanghai Acad Expt Med, Shanghai 200030, Peoples R China;[6]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou 730000, Peoples R China;[7]Lanzhou Univ, Clin Med Sch 1, Lanzhou 730000, Peoples R China;[8]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Clin Res Ctr, Chengdu 610072, Sichuan, Peoples R China;[9]Shanghai Jiao Tong Univ, Sch Med, Shanghai Chest Hosp, Inst Thorac Oncol,Dept Clin Lab Med, Shanghai 200030, Peoples R China;[10]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Ctr Med Genet & Rare Dis, Chengdu 610072, Sichuan, Peoples R China

第一机构：Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Heart Lung & Vessels Ctr, Chengdu 610072, Sichuan, Peoples R China

通信机构：[1]corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Heart Lung & Vessels Ctr, Chengdu 610072, Sichuan, Peoples R China;[2]corresponding author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Chest Hosp, Inst Thorac Oncol,Dept Clin Lab Med, Shanghai 200030, Peoples R China;[3]corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Ctr Med Genet & Rare Dis, Chengdu 610072, Sichuan, Peoples R China.

年份：2025

外文期刊名：ADVANCED SCIENCE

收录：;EI(收录号：20251118033858);Scopus(收录号：2-s2.0-86000276939);WOS:【SCI-EXPANDED(收录号:WOS:001438607200001)】；

基金：Y.Z. and C.D. contributed equally to this work. The Medical Ethics Committee of Sichuan Provincial People's Hospital approved this study (approval 2024-470). The authors obtained written informed consent from all participants who underwent blood collection. This work was financially supported by the National Natural Science Foundation of China (NSFC, 82070052, 82422042, 82372148, 823B2050, 824B2059), Non-profit Central Research Institute Fund of Chinese Academy of Medical Science (2020-PT320-005), Open Project of State Key Lab of Respiratory Disease (SKLRD-OP-202301), and Joint Fund of Science and Technology Department of Gansu Province (23JRRA1544).

语种：英文

外文关键词：diagnosis; laser desorption/ionization mass spectrometry; metabolic analysis; pulmonary hypertension caused by fibrosing mediastinitis; subtyping

摘要：Pulmonary hypertension (PH) often leads to poor survival outcomes and encompasses diverse subtypes with distinct underlying causes. Specifically, PH resulting from fibrosing mediastinitis (FM-PH) presents significant diagnostic challenges due to nonspecific symptoms and overlap of clinical characterization with other PH subtypes, leading to frequent misdiagnosis and delayed treatment. Moreover, the complex diagnostic procedures impose a significant burden on FM-PH patients, many of whom already experience mobility difficulties. This study represents a single test-based diagnosis of FM-PH, using the plasma metabolites obtained through ferric particle-enhanced laser desorption/ionization mass spectrometry analysis. Distinct metabolic alterations in FM-PH are identified compared to healthy controls and other PH subtypes, achieving an area under the curve (AUC) of 0.987 for FM-PH diagnosis and 0.728 for differentiating FM-PH from other subtypes. By addressing existing gaps in diagnostic strategies, this research highlights the potential of metabolic analysis in elucidating the metabolic landscape of PH.