文献类型：期刊文献

英文题名：The role of HIF-1α in hypoxic metabolic reprogramming in osteoarthritis

作者：Zhang, Jie[1];Gao, Peng[1];Chang, Wei-Rong[1];Song, Jia-Yi[1];An, Fang-Yu[3];Wang, Yu-Jie[2];Xiao, Zhi-Pan[2];Jin, Hua[4];Zhang, Xu-Hui[4];Yan, Chun-Lu[2,5]

第一作者：张杰

通信作者：Yan, CL[1];An, FY[2];Jin, H[3]

机构：[1]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou 73000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 73000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 73000, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou 73000, Gansu, Peoples R China;[5]Gansu Univ Chinese Med, Res Ctr Tradit Chinese Med Gansu, Lanzhou 73000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 73000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 73000, Gansu, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou 73000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：213

外文期刊名：PHARMACOLOGICAL RESEARCH

收录：;Scopus(收录号：2-s2.0-85217956465);WOS:【SCI-EXPANDED(收录号:WOS:001428314800001)】；

基金：This work was supported by the Joint Research Fund Project of Gansu Province (24JRRA879) , Natural Science Program in Gansu Province (24JRRA1026) , Innovation Fund Project of College Teachers of Gansu (2024A-089, 2025A-117, 2025B-125) , and Scientific Research Program by Gansu Chinese Medicine Bureau (GZKG-2024-88) .r Program by Gansu Chinese Medicine Bureau (GZKG-2024-88) .

语种：英文

外文关键词：Osteoarthritis; metabolic reprogramming; Hypoxia-inducible factor-1 alpha; Glycolysis

摘要：The joint dysfunction caused by osteoarthritis (OA) is increasingly becoming a major challenge in global healthcare, and there is currently no effective strategy to prevent the progression of OA. Therefore, better elucidating the relevant mechanisms of OA occurrence and development will provide theoretical basis for formulating new prevention and control strategies. Due to long-term exposure of cartilage tissue to the hypoxic microenvironment of joints, metabolic reprogramming changes occur. Hypoxia-inducible factor-1alpha (HIF-1 alpha), as a core gene regulating hypoxia response in vivo, plays an important regulatory role in the hypoxic metabolism of chondrocytes. HIF-1 alpha adapts to the hypoxic microenvironment by regulating metabolic reprogramming changes such as glycolysis, oxidative phosphorylation (OXPHOS), amino acid metabolism, and lipid metabolism in OA chondrocytes. In addition, HIF-1 alpha also regulates macrophage polarization and synovial inflammation, chondrocytes degeneration and extracellular matrix (ECM) degradation, subchondral bone remodeling and angiogenesis in the hypoxic microenvironment of OA, and affects the pathophysiological progression of OA. Consequently, the regulation of chondrocytes metabolic reprogramming by HIF-1 alpha has become an important therapeutic target for OA. Therefore, this article reviews the mechanism of hypoxia affecting chondrocyte metabolic reprogramming, focusing on the regulatory mechanism of HIF-1 alpha on chondrocyte metabolic reprogramming, and summarizes potential effective ingredients or targets targeting chondrocyte metabolic reprogramming, in order to provide more beneficial basis for the prevention and treatment of clinical OA and the development of effective drugs.