文献类型：期刊文献

中文题名：补肾通络方治疗糖尿病周围神经病变临床研究

英文题名：Clinical Study on Kidney-tonifying Collaterals-dredging Prescription in Treating Diabetic Peripheral Neuropathy

作者：杨维杰[1];任伯达[2];周春楠[2];刘晓[2]

第一作者：杨维杰

机构：[1]甘肃中医药大学附属医院,甘肃兰州730020;[2]甘肃中医药大学

第一机构：甘肃中医药大学第二附属医院

年份：2021

卷号：34

期号：9

起止页码：95

中文期刊名：西部中医药

外文期刊名：Western Journal of Traditional Chinese Medicine

收录：CSTPCD

语种：中文

中文关键词：糖尿病周围神经病变;阴虚兼瘀证;补肾通络方;临床研究

外文关键词：DPN;Yin deficiency complicated with stasis pattern;kidney-tonifying collateral-dredging prescription;clinical study

摘要：目的:观察补肾通络方联合甲钴胺对阴虚兼瘀型糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)患者症状及相关指标的干预效果。方法:将糖尿病周围神经病变阴虚兼瘀型患者60例随机分为两组各30例,试验组予甲钴胺+补肾通络方治疗,对照组予甲钴胺治疗,共治疗12周。观察两组患者治疗前后中医症状积分、多伦多临床评分系统(Toronto clinical scoring system,TCSS)评分、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、空腹血糖(fasting plasma glucose,FPG)、餐后2 h血糖(2 h post-prandial blood glucose,2hPG)及正中神经、腓总神经感觉传导速度(sensory nerve conduction velocity,SNCV)和运动传导速度(motor nerve conduction velocity,MNCV)。结果:1)试验组、对照组治疗前后中医症状积分、TCSS、FPG、2hPG、HbAlc及双侧腓总、正中神经MNCV、SNCV均较治疗前改善,差异有统计学意义(P<0.05);2)两组治疗后中医症状积分、TCSS、FPG、2hPG、HbAlc、双侧腓总神经MNCV、双侧正中神经SNCV比较差异有统计学意义(P<0.05)。3)试验过程中两组均未见肝肾功能损害,未见低血糖反应。结论:补肾通络方联合甲钴胺治疗阴虚兼瘀型糖尿病周围神经病变效果优于单纯甲钴胺治疗,且安全性较好。
Objective:To observe the intervention effects of kidney-tonifying collateral-dredging prescription joined with mecobalamin on the symptoms and the related indexes in the patients with DPN of Yin deficiency complicated with stasis pattern.Methods:Sixty patients were randomized into two groups,30 cases in each group,the experiment group took mecobalamin and kidney-tonifying collateral-dredging prescription,while the control group accepted oral administration of mecobalamin,both groups were treated for 12 weeks.To observe TCM symptom score,TCSS,HbA1c,FPG,2hPG,SNCV and MNCV of median nerve and common peroneal nerve before and after treating between both groups.Results:1)The difference had statistical meaning in TCM symptom scores,TCSS,FPG,2hPG,HbA1c,SNCV and MNCV of bilateral median nerve and common peroneal nerve before and after treating between the experiment group and the control group(P<0.05).2)The difference was statistically significant in TCM symptom score,TCSS,FPG,2hPG,HbA1c,SNCV and MNCV of median nerve and common peroneal nerve between both groups after treating(P<0.05).3)No damage to liver and kidney function happened during the process and no hypoglycemic reaction occurred in both groups.Conclusion:The effects of kidney-tonifying collateral-dredging prescription joined with mecobalamin in treating DPN of Yin deficiency complicated with stasis pattern are superior to these of only mecobalamin,and the therapy shows better safety.