文献类型：期刊文献

中文题名：幽门螺杆菌感染及相关代谢指标与肥胖关联的队列研究

英文题名：A cohort study on the association of Helicobacter pylori infection and related metabolic indicators with obesity

作者：任雪琳[1];扎西卓玛[1];张莹[1];冯渤曦[1];王凌鸿[1];王学军[1]

第一作者：任雪琳

机构：[1]甘肃中医药大学公共卫生学院,甘肃兰州730000

第一机构：甘肃中医药大学公共卫生学院

年份：2025

卷号：51

期号：5

起止页码：63

中文期刊名：兰州大学学报(医学版)

外文期刊名：Journal of Lanzhou University(Medical Sciences)

基金：国家自然科学基金资助项目(82160900)。

语种：中文

中文关键词：幽门螺杆菌;肥胖;队列研究;危险因素;代谢指标

外文关键词：Helicobacter pylori;obesity;cohort study;risk factor;metabolic indicators

摘要：目的 探讨幽门螺杆菌(Hp)感染及相关代谢指标与肥胖的关系。方法 采用队列设计研究,纳入2017年1月-2021年12月在甘肃中医药大学第四附属医院体检的1 952人进行Hp及相关生化指标的检测,分析其与肥胖的关联。结果 随访期间发生肥胖309例,Hp阳性组869例,发生肥胖238例,肥胖发生率为27.39%。对性别和年龄分组分析发现,Hp感染的男性及40~50岁年龄组的肥胖发生率明显高于女性及其他年龄段,差异具有统计学意义(P<0.001)。多因素Cox回归分析显示,Hp感染、高尿酸水平、高空腹血糖水平、脂肪肝为危险因素(P<0.05),高密度脂蛋白为保护因素(P<0.001);交互作用分析发现,Hp感染与高尿酸水平、高密度脂蛋白、脂肪肝对肥胖发生存在显著交互效应,HR(95%CI)分别为1.00[0.99,1.00]、6.15[1.34,28.18]、0.06[0.01,0.27]。结论 Hp感染及相关代谢指标与肥胖之间存在相关性,提示合理控制相关危险因素,可能有助于肥胖防控。
Objective To investigate the relationship between Helicobacter pylori(Hp)infection and related metabolic indicators and obesity.Methods A cohort design study was used to include 1952 people who underwent physical examination at The Fourth Affiliated Hospital of Gansu University of Traditional Chinese Medicine from January,2017 to December,2021 for the detection of Hp and related biochemical indexes,and to analyze its association with obesity.Results There were 309 cases of obesity during the follow-up period and 238 cases of obesity in the Hp-positive group(869 cases),with an obesity incidence of 27.39%.Analysis of gender and age groups revealed that the incidence of obesity in Hp-infected males and in the age group of 40 to 50 years was significantly higher than that of females and other age groups,and the difference was statistically significant(P<0.001).Multifactorial Cox regression analysis showed that Hp infection,high uric acid level,high fasting glucose level,and fatty liver were risk factors for obesity(P<0.05),and high-density lipoprotein was a protective factor(P<0.001);the interaction analysis found that there was a significant interactive effect between Hp infection and high uric acid level,high-density lipoprotein,and fatty liver in the development of obesity,with HR(95%CI)of 1.00[0.99,1.00],6.15[1.34,28.18],and 0.06[0.01,0.27],respectively.Conclusion A correlation exists between Hp infection and related metabolic indexes and the occurrence of obesity,suggesting that rational control of related risk factors may be helpful for obesity prevention and control.