文献类型：期刊文献

英文题名：Neuroplasticicity mechanism of acupuncture for pain-induced emotions: From function to structure

作者：Lu, Hong-yu[1];Wang, Bao-jin[1];Ma, Cui[1];Liu, An-guo[1];Yan, Xing-ke[1]

第一作者：Lu, Hong-yu

通信作者：Yan, XK[1]

机构：[1]Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学针灸推拿学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Lanzhou 730000, Peoples R China.|[10735db5df93766a96e5b]甘肃中医药大学针灸推拿学院;[10735]甘肃中医药大学;

年份：2025

卷号：35

期号：4

起止页码：276

外文期刊名：WORLD JOURNAL OF ACUPUNCTURE-MOXIBUSTION

收录：Scopus(收录号：2-s2.0-105015426861);WOS:【ESCI(收录号:WOS:001621434900001)】；

基金：The study was supported by 2025 Gansu Postgraduates' "Innovative Star" Project :2025CXZX-936; 2023 Gansu Provincial Key Talent Project :Gan Group General Word [2023] No. 20 ; 2023 Key Project of Scientific Research and Innovation Fund of Gansu University of Traditional Chinese Medicine :2023KCZD-6; Graduate Student "Innovation and Entrepreneurship Fund" Project of Gansu University of Traditional Chinese Medicine :2025CXCY-001; The study sponsor had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

语种：英文

外文关键词：Acupuncture; Pain-induced emotions; Neuroplasticity; Functional neuroplasticity; Structural neuroplasticity

摘要：Pain-induced emotions are the negative moods caused by pain, such as depression and anxiety. Acupuncture can effectively relieve pain-induced emotions, and its mechanism is closely related to the regulation of neuroplasticity. Neuroplasticity is composed of two types, functional neuroplasticity and structural neuroplasticity. (1) Acupuncture improves functional neuroplasticity by inhibiting the activation of microglia and astrocytes, regulating the expression of neurotransmitters and receptors, modulating cellular signal transduction pathways, and optimizing synaptic transmission efficiency. (2) Acupuncture improves structural neuroplasticity by modulating neuronal synaptic plasticity, inhibiting neuronal apoptosis, and up-regulating the expression of the BDNF/TrKB/CREB signaling pathway. Additionally, acupuncture up-regulates the expression of brain-derived neurotrophic factors to improve both the functional and structural neuroplasticity, thus relieves pain-induced emotions. The above discovery provides an approach to the mechanism research of acupuncture for pain-induced emotions. (c) 2025 World Journal of Acupuncture-Moxibustion House. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/)