文献类型：期刊文献

英文题名：Gut microbiota as a multifaceted modulator of prostate cancer: Mechanistic insights, therapeutic opportunities and clinical challenges (Review)

作者：Hao, Zhenming[1];Xie, Yongqiang[1];Zhang, Ru[1];Sang, Hui[1];Li, Luxi[1];Liu, Yulin[1];Hu, Jinbo[1];Wang, Jijun[1];Chai, Keqiang[1];Zhao, Qiang[1]

第一作者：Hao, Zhenming

通信作者：Chai, KQ[1];Zhao, Q[1]

机构：[1]Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Urol, 222 Silong Rd, Baiyin 730900, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Urol, 222 Silong Rd, Baiyin 730900, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：33

期号：2

外文期刊名：MOLECULAR MEDICINE REPORTS

收录：;Scopus(收录号：2-s2.0-105024739506);WOS:【SCI-EXPANDED(收录号:WOS:001649832200001)】；

基金：Not applicable.

语种：英文

外文关键词：prostate cancer; gut microbiota; dysbiosis androgen biosynthesis; resistance; therapeutic target

摘要：Prostate cancer (PCa) ranks among the most prevalent malignancies among men worldwide, emphasizing the need for innovative therapeutic strategies. Studies have suggested that the gut microbiota may markedly influence PCa pathogenesis through mechanisms such as immunomodulation and metabolic regulation. The present review systematically examined the composition and diversity of the gut microbiota, highlighted clinical evidence linking microbial dysbiosis to PCa risk and examined discrepancies in existing research. Additionally, it explored the therapeutic potential of microbiota modulation, through the use of probiotics and dietary interventions, in enhancing treatment responses. Despite emerging insights, challenges persist, including methodological variations and patient heterogeneity. The present review highlighted the need for further research to elucidate the role of the gut microbiota and support the development of personalized approaches for PCa management. The novelty of this work lay in its comprehensive synthesis of current evidence on the role of the gut microbiota in PCa, identification of gaps in existing research and proposal of future directions to advance our understanding of this emerging field.