文献类型：期刊文献

英文题名：Maternal iron and zinc and preterm labor risk: A nested case-control study based on the Lanzhou Birth Cohort Study (BBCS) in China

作者：Ding, Shuyu[1,2];Li, Yuqing[2];Wang, Jingyan[1,2];Cao, Lei[2];Wang, Zifu[2];Yang, Liping[3];Mao, Baohong[1,2,4]

第一作者：Ding, Shuyu

通信作者：Mao, BH[1];Mao, BH[2];Yang, LP[3]

机构：[1]Gansu Prov Matern & Childcare Hosp, Res Inst Clin Med Sci, 143 Qilihe North St, Lanzhou 730050, Gansu Province, Peoples R China;[2]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Gansu Province, Peoples R China;[3]Gansu Prov Hosp Tradit Chinese Med, Dept Publ Hlth & Infect Management, Lanzhou, Gansu Province, Peoples R China;[4]Gansu Prov Matern & Childcare Hosp, Dept Med Educ, Lanzhou, Gansu Province, Peoples R China

第一机构：Gansu Prov Matern & Childcare Hosp, Res Inst Clin Med Sci, 143 Qilihe North St, Lanzhou 730050, Gansu Province, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Matern & Childcare Hosp, Res Inst Clin Med Sci, 143 Qilihe North St, Lanzhou 730050, Gansu Province, Peoples R China;[2]corresponding author), Gansu Prov Matern & Childcare Hosp, Dept Med Educ, Lanzhou, Gansu Province, Peoples R China;[3]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Publ Hlth & Hosp Infect Management Dept, 418 Guazhou St, Lanzhou 730050, Gansu Province, Peoples R China.

年份：2025

卷号：34

期号：5

起止页码：839

外文期刊名：ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001675793200012)】；

基金：CONFLICT OF INTEREST AND FUNDING DISCLO-SURES The authors declare no conflict of interest. This work was supported in part by Youth innovation and entrepreneurship personnel training program of Gansu province (No.2021LQTD10) and the Science and Technology Department Grant of Lanzhou City (No.2021-1-85; 2022-5-85) .

语种：英文

外文关键词：iron; zinc; preterm; interaction; pregnancy; pregnancy

摘要：Background and Objectives: The aim of this study was to investigate the effect of dietary iron and zinc intake on the risk of preterm labor before and during different trimesters, and to assess whether there is an interaction between iron and zinc intake and the risk of preterm labor. Methods and Study Design: The study was a nested case-control study of 880 cases and 8017 controls in Lanzhou City, northwest China. Unconditional logistic regression was used to determine the association between dietary iron/zinc intake and the risk of preterm labor and its clinical subtypes. Multivariable-adjusted restricted cubic spline (RCS) modeling was used to explore the nonlinear relationship between dietary iron/zinc intake levels and the risk of preterm birth. Lower iron/zinc intake before and during pregnancy was associated with a higher risk of preterm labor and some of its subtypes, and there was a non-linear trend between iron/zinc intake and risk of preterm labor (p (non-linear)<0.05). A synergistic effect of low iron and zinc intake on the risk of preterm labor was also observed. Results: We observed a significant increase in the risk of preterm labor in women with low dietary zinc intake before and during pregnancy, with a dose-response relationship. Similarly, there was a significant negative association between lower dietary iron intake during pregnancy and preterm labor. In addition, there was a multiplicative interaction between low dietary iron and zinc intake and preterm delivery before pregnancy and during three different periods of pregnancy. Conclusions: Higher dietary intake of iron and zinc before and during pregnancy may reduce the risk of preterm labor. Low intakes of iron and zinc during pregnancy appear to have a synergistic effect on the risk of preterm labor.