文献类型：期刊文献

中文题名：神经肽Phoenixin的表达分布与功能机制的研究进展

英文题名：Research progress on the expression distribution and functional mechanism of neuropeptide Phoenix

作者：李嘉悦[1];刘立[1];何玲玲[1];侯悦晨[1]

第一作者：李嘉悦

机构：[1]甘肃中医药大学中西医结合学院,甘肃兰州730020

第一机构：甘肃中医药大学中西医结合学院

年份：2022

卷号：25

期号：5

起止页码：633

中文期刊名：中国实用神经疾病杂志

外文期刊名：Chinese Journal of Practical Nervous Diseases

收录：CSTPCD

基金：自然科学基金(编号:20JR10RA338);自然科学基金(编号:18JR3RA194);甘肃省中医药管理局科研课题(编号:GZK-2019-27)。

语种：中文

中文关键词：Phoenixin(PNX);表达分布;作用机制;下丘脑;GnRH

外文关键词：Phoenixin(PNX);expression distribution;functional mechanism;hypothalamus;GnRH

摘要：近年来,随着神经分子生物学和生物信息学的快速发展,以及人类基因组计划所提供的丰富信息,科学家从大鼠下丘脑和牛心脏中分离出了一种新的神经肽Phoenixin(PNX)。PNX有PNX-14和PNX-20两个亚型。PNX通过激活受体GPR173而广泛表达于多种动物的外周组织及中枢系统中,根据表达分布的不同,PNX起到了多种生物功能。综合近10 a的研究进展,本文总结了PNX在动物体内的表达分布以及在各表达位点的功能机制。PNX在下丘脑中的作用最为重要与复杂,可能与调节GnRH的脉冲式分泌有关。望能为PNX未来的研究理清思路,以期PNX成为新的诊断标志物和靶点治疗药物。
In recent years,with the rapid development of neuromolecular biology and bioinformatics and the rich information provided by the human genome project,scientists have isolated a new neuropeptide Phoenixin(PNX) from rat hypothalamus and bovine heart.PNX has two subtypes:PNX-14 and PNX-20.PNX is widely expressed in the peripheral tissues and central system of many animals by activating the receptor GPR173.According to the different expression distribution,PNX plays a variety of biological functions.Based on the research progress in recent 10 years,this paper summarizes the expression and distribution of PNX in animals,and expounds the functional mechanism of PNX at each expression site.The role of PNX in hypothalamus is the most important and complex,which may be related to regulating the pulsed secretion of GnRH.It is hoped that this paper can clarify the direction of PNX for the future research,in order to make PNX a new diagnostic marker or about a target therapeutic drug.