文献类型：期刊文献

中文题名：基于中医气血津液理论探讨细胞自噬与心肌缺血再灌注损伤的相关性

英文题名：Discussion on correlation between autophagy and myocardial ischemia-reperfusion injury from the theory of qi, blood and fluid in Chinese medicine

作者：杜婷婷[1];张志明[2]

第一作者：杜婷婷

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃中医药大学附属医院肿瘤科,兰州730000

第一机构：甘肃中医药大学

年份：2021

卷号：36

期号：12

起止页码：7086

中文期刊名：中华中医药杂志

外文期刊名：China Journal of Traditional Chinese Medicine and Pharmacy

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然科学基金项目(No.81660730)。

语种：中文

中文关键词：心肌缺血再灌注损伤;自噬;气血津液;病机

外文关键词：Myocardial ischemia-reperfusion injury;Autophagy;Qi;blood and fluid;Pathogenesis

摘要：多项研究发现中药可以通过调控自噬以减轻心肌缺血再灌注损伤(MIRI),MIRI的发病机制与气血津液有关,而自噬通过清除降解"无用"蛋白质产生能量以维持生命活动的功能与中医气血津液理论相契合,因此,研究MIRI病机与自噬的相关性就显得尤为重要。将自噬与气虚、血瘀、痰浊病机相结合,探求其相关性,为进一步探索自噬在MIRI治疗中的作用机制提供新思路。
Many studies have found that traditional Chinese medicine can reduce myocardial ischemia-reperfusion injury by regulating autophagy. The pathogenesis of myocardial ischemia-reperfusion injury is related to qi, blood and fluid, while autophagy’s function of maintaining life activities by removing and degrading ‘useless’ proteins is consistent with the theory of qi, blood and body fluid in traditional Chinese medicine. Therefore, it is particularly important to study the correlation between pathogenesis of myocardial ischemia-reperfusion injury and autophagy. Combining autophagy with pathogenesis of qi deficiency,blood stasis and phlegm turbidity, to explore its correlation and provide new ideas for further exploring the mechanism of autophagy in the treatment of myocardial ischemia-reperfusion injury.