文献类型：期刊文献

中文题名：自噬在胃癌发生发展和化疗中的作用

英文题名：Role of autophagy in the development and chemotherapy of gastric cancer

作者：陈刚[1,2];张敏敏[3];李玉民[1,2]

第一作者：陈刚

机构：[1]甘肃省消化系肿瘤重点实验室,兰州730030;[2]兰州大学第二医院普外一科,730030;[3]甘肃中医药大学临床医学院,兰州730030

第一机构：甘肃省消化系肿瘤重点实验室,兰州730030

年份：2019

卷号：36

期号：3

起止页码：580

中文期刊名：中华实验外科杂志

外文期刊名：Chinese Journal of Experimental Surgery

收录：CSTPCD;;北大核心:【北大核心2017】；CSCD:【CSCD_E2019_2020】；

基金：国家国际科技合作专项项目(2015DFA31650).

语种：中文

中文关键词：胃癌;自噬;化疗;多药耐药

外文关键词：Gastric cancer;Autophagy;Chemotherapy;Multidrug resistance

摘要：胃癌日益高发且有年轻化趋势,中国是高发地区之一,疗效、预后和国际水平比较尚有一定差距。胃癌的发生发展需经过癌前病变、早期胃癌、进展期胃癌等基本环节,自噬在上述各个环节中水平高低不一,产生的生物学效应亦有不同。化疗是胃癌治疗不可或缺的重要组成部分,自噬作为癌细胞和化疗药物交互作用的桥梁,影响癌细胞对化疗药物的敏感性甚至产生多药耐药。本文对自噬在胃癌发生发展和化疗过程中的作用及其机制加以论述,探讨如何通过调控自噬来阻止胃癌发生、逆转化疗耐药。
The morbidity of gastric cancer has increased greatly and it has a tendency to be younger. China is one of the areas with high incidence, and there is still a certain gap between efficacy and prognosis compared with the international level. The occurrence and development of gastric cancer goes through basic phases of pre-cancerous lesions, early gastric cancer and advanced gastric cancer. Autophagy level varies in the above-mentioned phases, and the biological effects are also different. Chemotherapy is an indispensable part of the treatment of gastric cancer. Autophagy acts as a bridge between cancer cells and chemotherapy drugs, affecting the sensitivity of cancer cells to chemotherapeutic drugs and even producing multidrug resistance. This manuscript discussed the role and mechanism of autophagy in the development and progression of gastric cancer as well as how to prevent gastric cancer by controlling autophagy and reverse drug resistance.