文献类型：期刊文献

中文题名：老年男性阻塞性睡眠呼吸暂停患者合并2型糖尿病发生脑卒中的风险

英文题名：Risk of cerebral stroke in elderly male OSA patients with T2DM

作者：贾晓清[1];苏小凤[3];韩继明[3];高莹卉[4];郭静静[5];林俊岭[6];高燕[7];陈开兵[8];刘霖[2]

第一作者：贾晓清

机构：[1]解放军总医院第一医学中心门诊部干部诊疗科,北京100853;[2]第二医学中心呼吸与危重症医学科国家老年疾病临床研究中心;[3]延安大学医学院;[4]北京大学国际医院睡眠中心;[5]北京大学人民医院呼吸科;[6]首都医科大学附属北京朝阳医院呼吸与危重症医学科;[7]解放军第九六○医院全科医学科;[8]甘肃中医药大学附属医院睡眠中心

第一机构：解放军总医院第一医学中心门诊部干部诊疗科,北京100853

年份：2022

卷号：24

期号：1

起止页码：55

中文期刊名：中华老年心脑血管病杂志

外文期刊名：Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

收录：CSTPCD;;北大核心:【北大核心2020】；

基金：军队保健专项科研课题(19BJZ34);国家老年疾病临床医学研究中心开放课题(NCRCG-PLAGH-2018008);解放军总医院军事医学青年成长项目(QNC19054);解放军总医院第二医学中心专项科研课题(ZXD2008)。

语种：中文

中文关键词：睡眠呼吸暂停,阻塞性;糖尿病,2型;卒中;高脂血症

外文关键词：sleep apnea,obstructive;diabetes mellitus,type 2;stroke;hyperlipidemias

摘要：目的探讨合并2型糖尿病对老年男性阻塞性睡眠呼吸暂停(OSA)患者脑卒中发生风险的影响。方法纳入2015年1月~2017年10月多中心老年男性OSA患者532例,以2型糖尿病为暴露因素分为糖尿病组135例和非糖尿病组397例,中位随访42(41,53)个月,记录患者临床症状、体征等,随访终点为发生的脑卒中事件。结果老年男性OSA患者合并2型糖尿病的发生率为25.4%。糖尿病组年龄、体质量指数、收缩压、舒张压、饮酒、随机血糖、糖化血红蛋白、冠心病、高血压、高脂血症、心房颤动及颈动脉粥样硬化比例明显高于非糖尿病组,差异有统计学意义(P<0.05,P<0.01)。随访期间发生脑卒中41例(7.7%)。糖尿病组的累积生存率低于非糖尿病组(P_(log rank)=0.003)。2型糖尿病是老年男性OSA患者脑卒中发生风险的独立危险因素(HR=2.344,95%CI:1.080~5.087,P=0.031)。结论2型糖尿病是老年男性OSA患者脑卒中发生风险的独立危险因素。
Objective To study the risk of cerebral stroke in elderly male obstructive sleep apnea(OSA)patients with type 2 DM(T2DM).Methods Five hundred and thirty-two elderly male OSA patients admitted to our center from January 2015 to October 2017 were divided into DM group(n=135)and DM-free group(n=397).The patients were followed up for 42(41,53)months,during which their clinical symptoms and signs,and end-point(cerebal stroke)were recorded.Results The incidence of T2DM was 25.4%in elderly male OSA patients.The age was significantly older,the alcohol consumption history was significantly longer,the BMI,SBP,DBP,incidence of CHD,hypertension,AF,hyperlipidemia,carotid atherosclerosis,and serum levels of random blood glucose and HbA1c were significantly higher in DM group than in DM-free group(P<0.05,P<0.01).Cerebral stroke occurred in 41 eldrly male OSA patients with an incidence of 7.7%during the follow-up period.The cumulative survival rate was significantly lower in DM group than in DM-free group(P_(log rank)=0.003).T2DM was an independent risk factor for cerebral stroke in elderly male OSA patients after adjustment of confounding factors(HR=2.344,95%CI:1.080-5.087,P=0.031).Conclusion T2DM is an independent risk factor for cerebral stroke in elderly male OSA patients.