文献类型：期刊文献

中文题名：肝细胞癌治疗的新视角:驱动基因的研究

英文题名：Driver Genes in Hepatocellular Carcinoma

作者：陈彻[1];张旭[1];苏亚珍[1]

第一作者：陈彻

机构：[1]甘肃中医药大学公共卫生学院,兰州730000

第一机构：甘肃中医药大学公共卫生学院

年份：2025

卷号：41

期号：3

起止页码：376

中文期刊名：中国生物化学与分子生物学报

外文期刊名：Chinese Journal of Biochemistry and Molecular Biology

收录：;北大核心:【北大核心2023】；

基金：青年科技基金(No.22JR11RA124);甘肃省自然科学基金(No.20JR10RA311);甘肃省中医药科研项目(No.GZKZ-2024-37);甘肃中医药大学科学研究与创新基金(No.2022KCYB-2);甘肃省创新之星(No.2023CXZX-768);兰州市科技计划项目(No.2023-2-12)资助。

语种：中文

中文关键词：驱动基因;肝细胞癌;端粒;细胞周期;表观遗传

外文关键词：driver gene;hepatocellular carcinoma(HCC);telomeres;cell cycle;epigenetics

摘要：肝细胞癌(hepatocellular carcinoma,HCC)是全球人类癌症相关死亡的第三大原因,虽然HCC的临床诊断和治疗取得了相当大的进展,但患者的预后仍较差,5年生存率仅约为18%。HCC的发生发展是由发生突变后能够直接促进细胞的增殖、存活和转移的驱动基因推动的,随着分子生物学和基因组学技术的发展,阐明了驱动基因突变赋予HCC细胞选择性生长优势,使细胞能够抵抗凋亡、维持增殖信号、启动侵袭和转移、诱导血管生成、实现代谢重塑和免疫逃逸等。探索HCC发生发展的关键驱动因素以进一步阐明HCC的发病机制,可为HCC的诊断、治疗以及改善预后提供新的方向。本文从端粒维持、细胞周期、Wnt信号通路、氧化应激、表观遗传修饰等多个方面总结了HCC中的驱动基因突变以及它们在HCC诊断和治疗中的应用前景,以期为HCC的诊断、治疗和研究提供信息参考。
Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths,and although considerable progress has been made in the clinical diagnosis and treatment of HCC,the prognosis for patients remains poor,with a 5-year survival rate of only about 18%.The development of HCC is driven by the occurrence of mutations in driver genes that can directly promote cell proliferation,survival and metastasis.With the development of molecular biology and genomics technologies,researchers have elucidated that driver mutations that give HCC cells a selective growth advantage,the ability of the cells to resist apoptosis,maintain proliferative signals,initiate invasion and metastasis,induce angiogenesis,enable metabolic remodeling and immune escape.Exploring the key drivers of HCC development to further elucidate the pathogenesis of HCC may provide new directions for the diagnosis and treatment of HCC as well as improving the prognosis.In this paper,we summarize the driver gene mutations in HCC from various biological pathways such as telomere maintenance,cell cycle,the Wnt signaling pathway,oxidative stress,and epigenetic modifications.We also summarize the application prospects of driver gene mutations in the diagnosis and treatment of HCC.We aim to provide a reference for the diagnosis,treatment and research of HCC.