文献类型：期刊文献

英文题名：Physical exercise therapy as an anti-aging strategy for osteosarcopenia: a narrative review

作者：Liu, Ting ting[1];Zhang, Pengwei[1];Dong, Wan tao[1,2];Gong, Yan long[1,2];Fang, Zhi jie[1];Li, Ning[1];Ma, Xin[1]

第一作者：Liu, Ting ting

通信作者：Zhang, PW[1];Dong, WT[1];Dong, WT[2]

机构：[1]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2026

卷号：7

外文期刊名：FRONTIERS IN AGING

收录：WOS:【ESCI(收录号:WOS:001789345200001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. 1. National Administration of Traditional Chinese Medicine Young Qihuang Scholars Training Program; 2. Lanzhou Chengguan District Talent Innovation and Entrepreneurship Project (2023-rc-7); 3. Gansu University of Chinese Medicine Science and Technology Achievement Transformation Cultivation Project (2023CGZH-5); 4. Intramural Training Project of the Affiliated Hospital of Gansu University of Chinese Medicine.

语种：英文

外文关键词：cellular senescence; non-pharmacological; osteosarcopenia; physical exercise therapy; review

摘要：With global population aging accelerating, osteosarcopenia-the coexistence of sarcopenia and osteoporosis-has become a critical health challenge leading to frailty, falls, and disability in the elderly. This syndrome is closely linked to chronic inflammation, metabolic imbalance, and cellular aging. Physical exercise therapy, as a non-pharmacological intervention, shows unique advantages in preventing musculoskeletal degeneration and restoring metabolic homeostasis. Evidence indicates that regular aerobic and resistance exercise promotes osteogenesis and muscle protein synthesis while inhibiting bone and muscle loss through mechanical loading, regulation of myokines and osteokines, and energy metabolism remodeling. Key molecular pathways include activation of the SIRT1/AMPK/PGC-1 alpha axis, modulation of mTOR signaling, and suppression of inflammatory cytokines such as IL-6 and TNF-alpha, which collectively enhance mitochondrial function and reduce oxidative stress. Moreover, physical exercise strengthens muscle-bone crosstalk via factors like irisin, myostatin, osteocalcin, and sclerostin, exerting systemic anti-aging effects. Future studies should emphasize personalized physical exercise prescriptions combined with biomarker monitoring and smart technologies to achieve sustainable musculoskeletal health and promote healthy aging.