文献类型：期刊文献

中文题名：中药复方治疗类风湿性关节炎的规律及其Logistic回归模型

英文题名：Regularity of Traditional Chinese Medicine Prescription for Rheumatoid Arthritis and Logistic Regression Analysis

作者：柳春[1];陈丽[1];梁永林[1]

第一作者：柳春

机构：[1]甘肃中医学院,兰州730000

第一机构：甘肃中医药大学

年份：2012

卷号：18

期号：21

起止页码：1

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2011】；

基金：甘肃省教育厅科研项目(0706B-09);甘肃中医学院中青年基金项目(06ZQ-10)

语种：中文

中文关键词：中药复方;类风湿性关节炎;规律

外文关键词：herbal prescription ; rheumatoid arthritis ; regularity

摘要：目的:研究中药复方治疗类风湿性关节炎的用药规律,建立中药特征与治疗类风湿性关节炎效应的数学模型,为实验研究及临床用药提供参考。方法:选取近30年公开发表临床疗效良好的中药治疗类风湿性关节炎复方376首,对复方中出现的205味药中使用频次最高的前50味药的功效、归经、药性、药味进行统计,并用多元判别分析建立Logistic回归数学模型。结果:袪风湿药和活血化瘀药比较活跃,其使用率为33.33%和25.71%,归膀胱经的使用率为23.68%,差异均有统计学意义(P<0.05)。采用逐步Logistic回归筛选主要因素,结果表明祛风湿药、活血化瘀药、平肝息风药、补虚药、解表药、清热药和归膀胱经的药均是具有治疗类风湿性关节炎效应的重要因素(回归系数>0,且P<0.01)。多元判别分析预测结果总符合率为90.0%。结论:中药特征与其治疗类湿性关节炎效应存在一定的规律,高频药是其所在功效、归经的代表用药,为临床医生选方用药提供参考依据。通过Logistic回归分析,得到结果与中医关于RA的病因病机、治则治法理论相吻合。
Objective： To analyze the regularity between traditional Chinese medicine （TCM＇s） characteristics and treatment of rheumatoid arthritis （RA） on the basis of the modern medical research literatures, establish a mathematic model in order to give a reference for clinical study and clinical prescription for treatment of RA with TCM＇s. Method： Articles about 376 RA-treating prescriptions with TCM＇s published were collected during the past 30 years, in which 50 medicines were identified as high frequency in 205 RA-treating medicines, and screened to summarize the number of 50 high frequency medicines with its different function, channel tropism, property and flavor. A mathematic model was established on the multivariate discriminatory analysis. Result： Medicines for rheumatism （33.33%）, those activating blood circulation and removing blood stasis （25.71%）, and medicines of utiinary bladder meridian （23.68%） were relatively active for treatment of RA and showed difference （P 〈 0.05）. According to the findings of the logistic regression screen, TCM＇s attribute to medicines for rheumatism, activating blood circulation and removing blood stasis, medicines for calming liver to stop endogenous wind heart, tonic, medicines for relieving exterior syndrome, heat-clearing medicines, and urinary bladder meridian medicines were important factors with therapeutic effect on RA （ regression coefficient 〉 0 and P 〈 0.01 ）. The coincidence was 90.0%. Conclusion： There are certain relationships between TCM＇s characteristics and its therapeutic effect on RA, the high frequency medicines are the representative on treatment of RA, and also give an important reference for clinical prescription. The result indicates the coincidence with relevant theories of the traditional Chinese medical science by the logistic regression analysis.