文献类型：期刊文献

中文题名：脓毒症诱导免疫抑制的调控机制及中药干预的研究现状

英文题名：Research status on the regulatory mechanism of immunosuppression induced by sepsis and Chinese medicine intervention

作者：苗开辉[1];董晨[1];王昱[2];王铮[2];王彦君[2]

第一作者：苗开辉

机构：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000;[2]甘肃中医药大学附属医院重症医学科,甘肃兰州730020

第一机构：甘肃中医药大学临床医学院

年份：2024

卷号：40

期号：23

起止页码：3497

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：CSTPCD;;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：甘肃省自然科学基金资助项目(23JRRA1580,21JR11RA152);甘肃省中医药管理局基金资助项目(GZKP-2022-21);兰州市城关区科技计划基金资助项目(2022-11-1)。

语种：中文

中文关键词：中药;脓毒症;免疫抑制;作用机制;研究现状

外文关键词：Chinese medicine;sepsis;immunosuppression;mechanism of action;research status

摘要：脓毒症的病理生理过程包括早期过度炎症反应及后期免疫抑制阶段,其与组织损伤相关并导致器官衰竭和内皮功能障碍。目前,脓毒症诱导免疫抑制的治疗以抗炎及增强机体免疫功能为主,缺乏特效的靶向治疗药物。中医药具有整体观念及辨证论治的优势,可以调节免疫抑制、抑制炎症反应,从而改善脓毒症诱导的免疫抑制状态。本文从脓毒症诱导免疫抑制的调控机制及中药干预机制等方面进行归纳总结,以期为脓毒症诱导免疫抑制的临床治疗及新药研发提供新思路。
The pathophysiological process of sepsis includes an early stage of excessive inflammation and a later stage of immunosuppression,which is associated with tissue damage and leads to organ failure and endothelial dysfunction.At present,the treatment of sepsis induced immunosuppression is mainly anti-inflammatory and enhancing immune function of the body,and there is a lack of specific targeted therapeutic drugs.Traditional Chinese medicine has the advantages of holistic concept and syndrome differentiation,which can regulate immunosuppression and inhibit inflammatory response,so as to improve the immunosuppression induced by sepsis.This article summarized the regulation mechanism of sepsis induced immunosuppression and the intervention mechanism of traditional Chinese medicine in order to provide new ideas for clinical treatment of sepsis induced immunosuppression and new drug development.