文献类型：期刊文献

英文题名：Biological mechanisms underlying the effects of low-magnitude mechanical stress in osteoporosis (Review)

作者：Liu, Zhi[1];Han, Dan[1];Wang, Yanfei[2];Li, Hongfan[1];Pei, Xuedong[1];Song, Zhijing[1,3]

第一作者：柳卓

通信作者：Song, ZJ[1];Song, ZJ[2]

机构：[1]Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Lanzhou 730000, Gansu, Peoples R China;[3]Minist Educ, Key Lab Dunhuang Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Minist Educ, Key Lab Dunhuang Med, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：32

期号：4

外文期刊名：EXPERIMENTAL AND THERAPEUTIC MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001869937400001)】；

基金：This work was supported by the Gansu Provincial Joint Scientific Research Fund (grant no. 24JRRA878), the Gansu Provincial Talent Project (grant no. 2025RCXM006), the Gansu Provincial Natural Science Foundation (grant no. 24JRRA1020), the Gansu Provincial Key Research and Development Program for International Scientific and Technological Cooperation (grant no. 25YFWA024) and the Graduate Innovation and Entrepreneurship Fund of Gansu University of Chinese Medicine (grant no. 2025CXCY-025).

语种：英文

外文关键词：osteoporosis; low-magnitude mechanical stress; bone remodeling; mechanotransduction; mesenchymal stem cells; osteoblasts; osteoclasts; vibration therapy

摘要：Osteoporosis is characterized by reduced bone strength and an increased risk of fracture. Low-magnitude mechanical stress (LMMS) has been investigated as a non-invasive stimulus capable of modulating mechanotransduction in bone cells. This review synthesizes evidence concerning integrin-cytoskeletal signaling, linker of nucleoskeleton and cytoskeleton-mediated nuclear force transmission, connexin 43-mediated intercellular communication and the downstream regulation of bone marrow mesenchymal stem cells, osteoblasts and osteoclasts. Preclinical studies indicate that LMMS can activate the Wnt/beta-catenin, MAPK/ERK, PI3K/AKT and receptor activator of nuclear factor-kappa B ligand/osteoprotegerin pathways in a context-dependent manner. However, clinical responses to whole-body vibration remain heterogeneous, vary according to the applied dose and skeletal site, and have not yet demonstrated fracture-prevention efficacy. Pulsed electromagnetic fields and therapeutic exercise are therefore discussed as related biophysical or mixed-magnitude interventions rather than as forms of LMMS itself. The present review highlights the gap between simplified cellular models and the three-dimensional bone microenvironment and proposes priorities for reporting standards and trial design to facilitate clinical translation.