文献类型：期刊文献

英文题名：Advances in the study of gut microecology and mechanisms of hyperuricemia and gouty arthritis

作者：Zhang, Youliang[1];Zhang, Hengyu[1];Miao, Tianwen[1];Wang, Xuetao[1];Zuo, Yanan[1];Zhang, Renwei[1];Zhang, Liangtong[1];Cheng, Yuan[1];Liu, Dong[2];Chen, Xin[1,3];Li, Longcan[1];Xie, Xingwen[1,3];Li, Ning[1,3]

第一作者：张亚玲;张玉玲;张玉兰

通信作者：Xie, XW[1];Li, N[1];Xie, XW[2];Li, N[2]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China;[2]Sichuan Prov Orthoped Hosp, Chengdu, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2026

卷号：16

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-105028561412);WOS:【SCI-EXPANDED(收录号:WOS:001667054500001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This research was supported by the Gansu University of Chinese Medicine Graduate Innovation and Entrepreneurship Fund (NO. 2025CXCY-015, NO. 2025CXZX-927, NO. 2025CXZX-914), the Lanzhou Talent Innovation and Entrepreneurship Project (NO. 2021-RC-88), the National Natural Science Foundation of China (NO. 82060873, NO. 82174412, NO. 82374491, NO. 82160911), and the Gansu Provincial Higher Education Industry Support Program (NO. 2023CYZC-57). The Science and Technology Major Special Fund (22ZD6FA021-4), the Open Fund of the Affiliated Hospital of Gansu University of Chinese Medicine A(2023kKF-02).

语种：英文

外文关键词：gouty arthritis; gut microbes; gut microbiota; intestinal barrier; novel therapeutic perspectives

摘要：Gouty arthritis is a metabolic disorder caused by purine metabolism dysregulation, characterized by monosodium urate crystal deposition in and around joints, triggering acute articular inflammation via NLRP3 inflammasome activation and IL-1 beta-mediated inflammatory cascades. While hyperuricemia represents a critical biochemical prerequisite for gouty arthritis development, elevated serum urate levels do not invariably lead to the disease. Mounting evidence suggests a significant relationship between gut microbiota and the pathogenesis of both gouty arthritis and hyperuricemia. The gut microbial ecosystem influences host health through metabolic and immune function modulation, performing essential roles in digestion, energy harvesting, and short-chain fatty acid production. Intestinal dysbiosis can damage epithelial integrity, compromise immune tolerance, and activate immune cells, thus contributing to disease onset and progression. Elucidating the complex interactions between gut microbiota and the mechanisms underlying gouty arthritis and hyperuricemia presents promising opportunities for developing novel preventative and therapeutic interventions. This review synthesizes recent advances in understanding the gut-joint axis and evaluates emerging therapeutic strategies including probiotics, dietary interventions, and fecal microbiota transplantation.