文献类型：期刊文献

英文题名：Pharmacological basis of Codonopsis Radix in COPD: Lobetyolin modulates Nrf2/NF-κB-mediated inflammation and oxidative stress

作者：Chen, Zhengjun[1];Shi, Qi[1];Wang, Chunxia[1];Zhang, Zhihong[1];Yang, Jie[2];Luo, Wenrong[3];Yang, Fude[1]

第一作者：陈正君

通信作者：Yang, FD[1];Luo, WR[2]

机构：[1]Gansu Univ Chinese Med, Sch Pharm, Lanzhou, Gansu, Peoples R China;[2]Beijing Univ Chinese Med, Beijing, Peoples R China;[3]Gansu Prov Hosp Tradit Chinese Med, Dept Pharm, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Pharm, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Dept Pharm, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：363

起止页码：121383

外文期刊名：JOURNAL OF ETHNOPHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-105033516332);WOS:【SCI-EXPANDED(收录号:WOS:001701681500001)】；

基金：This work was supported by the Key Laboratory Project of Quality Control for Traditional Chinese Medicine Materials and Decoction Pieces, National Medical Products Administration (Grant No. 2024GSMPA-KL/5) ; the Gansu Provincial Drug Regulatory Science Research Project (Grant No. 2025GSMPA072) ; the Industry Support Program for Higher Education Institutions of Gansu Province (Grant No. 2021CYZC-40) ; the Key Research and Development Program of Gansu Province-Social Development Category (Grant No. 23YFFA0069) ; and the Open Project of the Gansu Province Research Center of Traditional Chinese Medicine (Grant No. zyzx-2023-10) .

语种：英文

外文关键词：Codonopsis Radix; Lobetyolin; COPD; Nrf2/NF-kappa B signaling pathway; Pharmacodynamic substances; Inflammatory microenvironment

摘要：Ethnopharmacological relevance: Codonopsis Radix (CR), a traditional Chinese medicinal herb, tonifies the lung and promotes fluid production. It serves as an effective and commonly used remedy for pulmonary diseases. Chronic obstructive pulmonary disease (COPD) is a common respiratory disease in which inflammation and oxidative stress are central to disease pathogenesis. Lobetyolin (LBT), a bioactive constituent of CR, exhibits antiinflammatory and antioxidant activities; however, its efficacy and underlying mechanisms in COPD remain unclear. Aim of the study: This study aims to identify the active components of Wen Codonopsis Radix (WCR) for the treatment of COPD, and to elucidate the mechanism by which LBT alleviates COPD by regulating the Nrf2/NF-kappa B signaling pathway. Materials and methods: Male SPF-grade C57BL/6J mice were used to establish a CSE/LPS-induced COPD model. The active fraction of WCR was screened by pharmacodynamic evaluation. Potential active components and signaling pathways within the most effective fraction were predicted using UHPLC-QE-MS combined with network pharmacology. Candidate bioactive constituents were further quantified by HPLC to substantiate their chemical relevance. In a CSE/LPS-induced BEAS-2B cell injury model, the mechanism of LBT was investigated with a focus on the Nuclear factor erythroid 2-related factor 2 (Nrf2)/Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) signaling pathway. Results: The ethyl acetate fraction of WCR alleviated CSE/LPS-induced lung injury in COPD mice, and LBT emerged as a potential active component for COPD treatment. In CSE/LPS-induced BEAS-2B cells, LBT significantly reduced inflammation and oxidative stress, modulated the Nrf2/NF-kappa B pathway, upregulated SOD expression, and decreased IL-8, TNF-alpha, and MDA levels. Collectively, these effects attenuated COPD development and progression.
Conclusion: LBT alleviates inflammation and oxidative stress, delays COPD progression, and ameliorates lung injury by activating Nrf2, inhibiting NF-kappa B signaling, and restoring Nrf2/NF-kappa B homeostasis. This study provides a theoretical basis for elucidating the "quality-effect" relationship of WCR and supports its product development.