文献类型：期刊文献

英文题名：Alteration of tumor characteristics following neoadjuvant treatment in gastric adenocarcinoma: a case report

作者：Peng, Lingzhi[1];Ma, Zhanying[2];Zhao, Yunfei[2];Ma, Hong[3];Liu, Weijun[4];Huang, Ming[5]

第一作者：Peng, Lingzhi

通信作者：Huang, M[1]

机构：[1]Gansu Prov Hosp, Dept Surg Oncol, Lanzhou, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Sch Clin Med 1, Lanzhou, Peoples R China;[3]Gansu Prov Hosp, Dept Intervent Oncol, Lanzhou, Peoples R China;[4]Longxi Cty First Peoples Hosp, Dept Gen Surg, Longxi, Peoples R China;[5]Gansu Prov Hosp, Dept Neurosurg, Lanzhou, Peoples R China

第一机构：Gansu Prov Hosp, Dept Surg Oncol, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Neurosurg, Lanzhou, Peoples R China.

年份：2026

卷号：16

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001686976600001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by the General Project of Joint Research Fund of Gansu Provincial Science and Technology Program (Grant No. 25JRRA1201).

语种：英文

外文关键词：chemotherapy; gastric cancer; gastric neuroendocrine tumor; neoadjuvant therapy; tumor biological behavior

摘要：A 69-year-old female was admitted to the hospital with abdominal pain and distension. Gastroscopy revealed an irregular protruding lesion on the lesser curvature of the gastric fundus, and pathological examination indicated moderately to poorly differentiated adenocarcinoma. Enhanced abdominal computed tomography (CT) identified a space-occupying lesion at the gastric fundus with multiple enlarged lymph nodes. The initial diagnosis was moderately to poorly differentiated adenocarcinoma, cT3N3M0 (Stage IIIa). The patient subsequently underwent neoadjuvant therapy comprising albumin-bound paclitaxel, camrelizumab, oxaliplatin, and S-1.After four cycles, the tumor significantly reduced in size, with restaging at yT2N2M0 (Stage IIb). Following multidisciplinary team (MDT) consultation, the patient underwent radical total gastrectomy with esophagojejunostomy. Postoperative recovery was uneventful, and the patient was discharged in improved condition. Notably, postoperative pathological analysis revealed a neuroendocrine tumor, demonstrating an alteration in tumor histology after neoadjuvant therapy for gastric cancer (GC).