文献类型：期刊文献

英文题名：Predictive model of gene expression regulating invasion and migration of M2 macrophages in breast cancer: clinical prognosis and therapeutic implications

作者：Jiang, Chengjie[1];Luo, Jinlei[1];Jiang, Xiaoxue[2];Lv, Yujie[1];Dou, Jianwei[3]

第一作者：Jiang, Chengjie

通信作者：Dou, JW[1]

机构：[1]Lab TCM New Prod Dev Engn Gansu Prov, Key Lab Tradit Chinese Herbs & Prescript Innovat &, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Sch Chinese Clin Med, Lanzhou, Peoples R China;[3]Xi An Jiao Tong Univ, Sch Pharm, 76 Yanta West Rd, Xian 710000, Peoples R China

第一机构：Lab TCM New Prod Dev Engn Gansu Prov, Key Lab Tradit Chinese Herbs & Prescript Innovat &, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Xi An Jiao Tong Univ, Sch Pharm, 76 Yanta West Rd, Xian 710000, Peoples R China.

年份：2024

卷号：13

期号：8

起止页码：4187

外文期刊名：TRANSLATIONAL CANCER RESEARCH

收录：;Scopus(收录号：2-s2.0-85202714343);WOS:【SCI-EXPANDED(收录号:WOS:001318838100003)】；

基金：conducted in accordance with the Declaration of Helsinki (as revised in 2013) . We are grateful to the anonymous reviewers for their constructive comments on the original manuscript. Funding: This work was supported by the National Natural Science Foundation of China (No. 82074374) .

语种：英文

外文关键词：M2 macrophages; breast cancer (BRCA); gene expression regulating; prognosis model; invasion migration

摘要：Background: Breast cancer (BRCA) has surpassed lung cancer to become the malignant tumor with the highest incidence in female population. It occurs in malignant cells in breast tissue and is common worldwide. An increasing body of research indicates that M2 macrophages are critical to the occurrence and progression of BRCA. The aim of this work is to build a predictive model of genes related to invasion and migration of M2 macrophages, forecast the prognosis of patients with BRCA, and then evaluate the efficacy of some targeted treatments. Methods: The Gene Expression Omnibus (GEO; https://www.ncbi.nlm.nih.gov/geo/) database supplied the GSE20685 dataset, whereas the expression profile a clinical details of BRCA patients were obtained from The Cancer Genome Atlas (TCGA; https://portal.gdc.cancer.gov/) database. The genes linked to M2 macrophages and the differentially elevated genes of invasion and migration were found in GSE20685. To explore the prognosis-related invasion and migration M2 macrophage genes, the TCGA-BRCA dataset was merged with Cox regression and least absolute shrinkage and selection operator (LASSO) regression. GSE58812 was utilized for external validation. After calculating each patient's risk score, the prognostic model was examined by analyses of immune infiltration, medication sensitivity, mutation, and enrichment of the risk score. Results: The risk score had a strong correlation with both several immune cells and popular anti-tumor medications. Additionally, it was discovered that the risk score was a separate prognostic factor for BRCA. Conclusions: Based on invasion and migration-related M2 macrophage genes, we investigated and validated predictive characteristics in our study that may offer helpful insights into the progression and prognosis of BRCA.