文献类型：期刊文献

英文题名：Variations of energy metabolism and adenosine Triphosphatase activity in gastric mucosa in chronic atrophic gastritis rats with Qi deficiency and blood stasis syndrome and effect of Zhiweifangbian capsule

作者：Duan, Yongqiang[1,2];Cheng, Weidong[1];Cheng, Yingxia[2];Li, Hongyan[2];Li, Xueyan[1];Zhu, Liming[2];Yang, Xiaoyi[2]

第一作者：段永强;Duan, Yongqiang

通信作者：Cheng, WD[1]

机构：[1]Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Chinese & Western Med, Lanzhou 730020, Gansu, Peoples R China;[2]Gansu Coll Tradit Chinese Med, Dept Basic Courses, Lanzhou 730020, Peoples R China

第一机构：Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Chinese & Western Med, Lanzhou 730020, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Chinese & Western Med, Lanzhou 730020, Gansu, Peoples R China.

年份：2013

卷号：33

期号：4

起止页码：500

外文期刊名：JOURNAL OF TRADITIONAL CHINESE MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000323142600015)】；

基金：Supported by National Natural Science Fund (No. 81260519); Science and Technique Plan of the Administration of Traditional Chinese Medicine of Gansu Province (No. 07-GZK-07) and Experimental Plan for Young and Middle-aged Teacher of Gansu College of Traditional Chinese Medicine (No. 05ZQ-03/09ZQ-09)

语种：英文

外文关键词：Qi deficiency blood stasis; Gastritis, atrophic; Lactic dehydrogenase; Succinate dehydrogenase; Zhiweifangbian capsule

摘要：OBJECTIVE: To study the effects of Zhiweifangbian (ZWFB) capsule on lactic dehydrogenase (LDH), succinic dehydrogenase (SDH) and ATPase activities in gastric mucosa of chronic atrophic gastritis (CAG) rats with Qi deficiency and blood stasis syndrome. METHODS: Totally 90 rats were randomly divided into 2 groups: normal group (n=10) and model group (n=80). The CAG rat model of Qi deficiency and blood stasis type was induced by synthetic methods. After modeling for 12 weeks and the successful CAG model was determined, the CAG model rats were divided by random number table into model group (MG), ZWFB high-dose group (ZWFBH), ZWFB middle-dose group (ZWFBM), ZWFB low-dose group (ZWFBL) and Weimeisu group (WM), 9 rats in each group. The rats in the normal and model groups were intragastrically administrated with distilled water, 10 mL/kg every day; the ZWFB high-dose group with ZWFB, 0.6 g/kg(-1) . d(-1); the ZWFB middle-dose group with ZWFB, 0.3 g/kg(-1) . d(-1); the ZWFB low-dose group with ZWFB, 0.15 g/kg(-1) . d(-1), and the WM group with suspension of WM, 0.25 g/kg(-l) . d(-1). The treatment was given for 90 consecutive days. Then general survival states were observed and the activities of LDH, SDH, Na+-K+-ATPase and Ce2+-Mg2+-ATPase in gastric mucosa tissue were detected. RESULTS: Compared with the normal group, activity of LDH in the gastric mucosa (P<0.05) and activities of SDH, Na+-ATPase and Ca2+-Me-ATPase significantly decreased in the normal group (P<0.05). Compared with the model group the activity of LDH decreased and activities of SDH, Na+-K+-ATPase and Ce2+-Mg2+-ATPase significantly increased in the high dose ZWFB group (P<0.05). CONCLUSION: ZWFB capsule can promote energy metabolism and ATPase activity in the gastric mucosa cell, so as to protect the function of the gastric mucosa cell. (C) 2013 JTCM. All rights reserved.