文献类型：期刊文献

中文题名：逍遥散对阿尔茨海默病模型小鼠学习记忆及神经递质的影响

英文题名：Effect of xiaoyao powder on the ability of learning and memory and neurotransmitter activity of Alzheimer's disease model mice

作者：王虎平[1];邢喜平[2];张雯娟[1];吴红彦[1]

第一作者：王虎平

机构：[1]甘肃中医学院基础医学院甘肃省中药药理与毒理学重点实验室甘肃省中药新产品创新工程实验室,甘肃兰州730000;[2]甘肃中医学院附属医院

第一机构：甘肃中医药大学基础医学院（敦煌医学研究所）|甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）

年份：2014

卷号：34

期号：9

起止页码：2468

中文期刊名：中国老年学杂志

外文期刊名：Chinese Journal of Gerontology

收录：CSTPCD;;北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

基金：国家自然科学基金项目(No.81060284);甘肃中医学院中青年基金项目(No.2010-11);甘肃省中药药理与毒理学重点实验室开放基金(No.zdsys-kj-2013-010)

语种：中文

中文关键词：逍遥散;阿尔茨海默病;学习记忆;神经递质

外文关键词：Xiaoyao powder;;Alzheimer's Disease;;Learning and memory;;Neurotransmitter

摘要：目的研究逍遥散对氢溴酸东莨菪碱致阿尔茨海默病(AD)模型小鼠学习记忆能力及神经递质活性的影响。方法 50只SPF级KM小鼠随机分为空白组、模型组、逍遥散低、中、高剂量组,腹腔注射氢溴酸东莨菪碱复制AD小鼠模型并以逍遥散不同剂量进行干预防治,给药第6、8天水迷宫训练各组小鼠学习能力,第10天测定小鼠记忆能力,然后取脑组织测胆碱乙酰转移酶(ChAT)、乙酰胆碱酯酶(AchE)及单胺氧化酶(MAO)活性。结果逍遥散低、中、高剂量组均可提高小鼠学习记忆能力,降低潜伏时间,提高脑组织匀浆ChAT活性,降低AchE及MAO活性,但学习记忆能力及神经递质活性的改善皆以逍遥散高剂量组最为明显。结论逍遥散能较好改善AD模型小鼠学习记忆及神经递质活性,对AD具有较好的防治作用。
Objective To observe the effect of xiaoyao powder on the ability of learning and memory and neurotransmitter activity of Alzheimer′s disease ( AD) model mice made by scopolamine hydrobromide and investigate the effect and mechanism of xiaoyao powder trea -ting AD.Methods 50 SPF KM mice were randomly divided into blank control , model and low, middle, high dose xiaoyao powder groups . AD mice model was induced by scopolamine hydrobromide alkali intraperitoneal injection and prevented by different dosage of xiaoyao pow -der, brain tissue was measured after 1 h of injecting of scopolamine hydrobromide ,the levels of ChAT, AchE, MAO activity in brain tissue homogenate were detected .Results Different dosage of xiaoyao powder improved learning and memory ability and lower average latency time and improved ChAT activity and lower AchE and MAO content ,and high dose group of Xiaoyao powder was most obvious .Conclusions Xi-aoyao powder can better improve learning and memory ability and neurotransmitter activity of AD model mice and has good control effect on ADN.