文献类型：期刊文献

英文题名：Effects of different processing (Paozhi) methods on the structural characteristics and bidirectional immunomodulatory activities of Astragalus polysaccharides

作者：Zhao, Ning[1,2,3,4];Li, Yunchun[2,3];Qu, Qingli[2,3];Shao, Jing[1,4,5,6];Pei, Dong[1,2,3];Liu, Jianfei[1,2,3]

第一作者：Zhao, Ning

通信作者：Shao, J[1];Pei, D[1];Liu, JF[1];Pei, D[2];Liu, JF[2];Pei, D[3];Liu, JF[3]

机构：[1]Gansu Univ Tradit Chinese Med, Sch Pharm, Lanzhou 730000, Peoples R China;[2]Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China;[3]Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China;[4]State Adm Tradit Chinese Med, Tertiary Lab, Key Lab Tradit Chinese Med Chem, Lanzhou 730000, Peoples R China;[5]Northwest Chinese & Tibetan Med Prov Minist Collab, Lanzhou 730000, Peoples R China;[6]Prov Key Lab Chem & Qual Res Chinese Tibetan Med G, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Sch Pharm, Lanzhou 730000, Peoples R China;[2]corresponding author), Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China;[3]corresponding author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：221

外文期刊名：FOOD RESEARCH INTERNATIONAL

收录：;EI(收录号：20253819192356);Scopus(收录号：2-s2.0-105016099661);WOS:【SCI-EXPANDED(收录号:WOS:001619777400002)】；

基金：This work was financially supported by the Youth Innovation Pro-motion Association CAS (No. 2023442) , Central Government Guidance Funds for Local Scientific and Technological Development China (No. 24ZYQJ002) , Lanzhou Talent Innovation and Entrepreneurship Project (No. 2023-RC-4) , Lanzhou Science and Technology Plan Project (No. 2022-2-2) , Key Research and Development Program of Gansu Province (No. 22YF7NA027) , the Qingdao Municipal Bureau of Science and Technology (No. 24-1-4-xxgg-17-nsh) , Key R & D Program of Yunnan Province (No. 202203AD150003) , Yunnan Province Major Scientific and Technological Project (No.202302AE090007) . The authors also are grateful to anonymous reviewers for their comments and peer review.

语种：英文

外文关键词：Astragalus polysaccharides; Processing methods (Paozhi); Structural characterization; Immune enhancement; Anti-inflammatory

摘要：Astragalus polysaccharides (APSs) have a wide range of biological activities. In this study, four APSs, namely RAPSs, SAPSs, WAPSs, and HAPSs, were prepared from the raw and three processed (Paozhi) Astragali Radix tablets with these classic Chinese medicine processing stir-fried methods with salt, yellow rice wine, and honey. The structure and bidirectional immunomodulatory activities of four APSs were investigated. The results revealed that different processing methods of Astragali Radix tablets altered the structure of APSs and thus affected their bidirectional immunomodulatory activities. RAPSs, SAPSs, WAPSs, and HAPSs showed significant differences in chemical composition, molecular weight, monosaccharide composition, chain conformation, surface morphology, and immune-enhancing and anti-inflammatory activities. Among the four APSs, HAPSs exhibited the strongest immune-enhancing effects, while WAPSs showed the most potent anti-inflammatory ability. The findings provide a scientific rationale for the development and optimal utilization of APSs in the domains of food and medicine fields.