文献类型：期刊文献

英文题名：Role of reactive oxygen species and mitochondrial damage in rheumatoid arthritis and targeted drugs

作者：Jing, Weiyao[1];Liu, Cui[1];Su, Chenghong[1];Liu, Limei[1];Chen, Ping[2];Li, Xiangjun[2];Zhang, Xinghua[3];Yuan, Bo[4];Wang, Haidong[2];Du, Xiaozheng[1]

第一作者：Jing, Weiyao

通信作者：Du, XZ[1];Wang, HD[2]

机构：[1]Gansu Univ Chinese Med, Dept Acupuncture Moxibust & Tuina, Lanzhou, Peoples R China;[2]Gansu Prov Hosp Tradit Chinese Med, Dept Rheumat & Bone Dis, Lanzhou, Peoples R China;[3]Gansu Prov Hosp Tradit Chinese Med, Dept Acupuncture, Lanzhou, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Dept Acupuncture & Pain, Affiliated Hosp, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Dept Acupuncture Moxibust & Tuina, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Dept Rheumat & Bone Dis, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：14

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-85148646580);WOS:【SCI-EXPANDED(收录号:WOS:000935266100001)】；

语种：英文

外文关键词：rheumatoid arthritis; reactive oxygen species; mitochondrial damage; targeted drugs; oxidative stress

摘要：Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation, pannus formation, and bone and cartilage damage. It has a high disability rate. The hypoxic microenvironment of RA joints can cause reactive oxygen species (ROS) accumulation and mitochondrial damage, which not only affect the metabolic processes of immune cells and pathological changes in fibroblastic synovial cells but also upregulate the expression of several inflammatory pathways, ultimately promoting inflammation. Additionally, ROS and mitochondrial damage are involved in angiogenesis and bone destruction, thereby accelerating RA progression. In this review, we highlighted the effects of ROS accumulation and mitochondrial damage on inflammatory response, angiogenesis, bone and cartilage damage in RA. Additionally, we summarized therapies that target ROS or mitochondria to relieve RA symptoms and discuss the gaps in research and existing controversies, hoping to provide new ideas for research in this area and insights for targeted drug development in RA.