文献类型：期刊文献

中文题名：STAT6介导信号网络调控变应性鼻炎及中药干预作用的研究进展

英文题名：Research Progress of STAT6-mediated Signal Network Regulating Allergic Rhinitis and the Intervention Effect of Traditional Chinese Medicine

作者：赵跃[1];全苹[1];王志旺[1];梁可克[1];黄柯婷[1];张悦[1];赵高斯[2]

第一作者：赵跃

机构：[1]甘肃中医药大学药学院,兰州730000;[2]甘肃中医药大学附属医院,兰州730020

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2025

卷号：42

期号：6

起止页码：1044

中文期刊名：中国现代应用药学

外文期刊名：Chinese Journal of Modern Applied Pharmacy

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金项目(82260852、81460668);甘肃省自然科学基金项目(20JR5RA183、1606RJZA011、1310RJZA086)。

语种：中文

中文关键词：变应性鼻炎;信号转导和转录激活因子6;信号网络;中药;作用机制

外文关键词：allergic rhinitis;signal transducer and activator of transcription 6;signal network;traditional Chinese medicine;mechanism

摘要：变应性鼻炎(allergic rhinitis,AR)是一种由免疫球蛋白E(immunoglobulin E,IgE)介导、2型辅助T细胞(T helper 2cell,Th2)优势应答引起的免疫炎症性疾病。信号转导和转录激活因子6(signal transducer and activator of transcription 6,STAT6)作为介导Th2细胞的关键转录因子,通过多种信号通路广泛参与AR鼻腔炎症反应、高反应性、黏液高分泌以及重塑等病理过程。近年来研究发现,STAT6介导白介素-4(interleukin-4,IL-4)、白介素-13(interleukin-13,IL-13)及GATA结合蛋白3(GATA-binding protein 3,GATA3)等信号通路与AR有密切的关系。中药可明显降低AR的复发率,研究显示通过STAT6介导的信号网络降低IgE水平、缓解Th2细胞免疫炎症反应是中药治疗AR的重要作用机制。本文通过检索相关数据库,对STAT6介导上述相关信号网络调控AR以及中药干预作用进行综述,以期为AR的实验研究与新药开发提供理论基础。
Allergic rhinitis(AR) is an immune inflammatory disease primarily caused by an immune system response involvingimmunoglobulin E(IgE) and T helper 2 cell(Th2) dominance.As a key transcription factor mediating Th2 cells,signal transducerand activator of transcription 6(STAT6) is widely involved in variously physiopathological processes such as immune-inflammatoryresponse,hyperreactivity,mucus hypersecretion and nasal remodeling in the AR nasal cavity through multiple signaling networks.Recent studies have found that STAT6 mediates signaling pathways involving interleukin-4(IL-4),interleukin-13(IL-13),andGATA-binding protein 3(GATA3),which are closely associated with AR.Traditional Chinese medicine has been shown tosignificantly reduce the recurrence rate of AR.Studies indicate that its therapeutic mechanisms involve modulating the STAT6-mediated signaling network to lower IgE levels and alleviate Th2 cell-mediated immune inflammatory responses,which are criticalpathways in traditional Chinese medicine treatment for AR.By reviewing literature from relevant databases,this paper summarizesthe regulatory role of the STAT6-driven signaling network in AR pathogenesis and the interventional effects of traditional Chinesemedicine,aiming to provide a theoretical foundation for experimental research and novel drug development targeting AR.