文献类型：期刊文献

英文题名：The protective role of muscone in the development of COPD

作者：Feng, Tiantian[1];Guo, Xiaolong[1];Chen, Wei[2];Zhang, Yanying[3];Dai, Runjing[4];Zhang, Yinfang[5];Liu, Yongqi[6];Liu, Yiya[7];Song, Peng[5];Fan, Jingchun[1]

第一作者：Feng, Tiantian

通信作者：Fan, JC[1];Song, P[2];Liu, YY[3]

机构：[1]Gansu Univ Chinese Med, Ctr Evidence Based Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;[2]Lanzhou Inst Biol Prod Co Ltd, Qual Assurance Dept, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[4]Xian Aerosp Gen Hosp, Hosp Infect Control Dept, Xian, Shanxi, Peoples R China;[5]Gansu Univ Chinese Med, Expt & Achievement Transformat Ctr, Affiliated Hosp, Lanzhou, Gansu, Peoples R China;[6]Gansu Univ Chinese Med, Key Lab Dunhuang Med, Minist Educ, Lanzhou, Gansu, Peoples R China;[7]Gansu Med Coll, Sch Publ Hlth, Pingliang, Gansu, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Ctr Evidence Based Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Expt & Achievement Transformat Ctr, Affiliated Hosp, Lanzhou, Gansu, Peoples R China;[3]corresponding author), Gansu Med Coll, Sch Publ Hlth, Pingliang, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;

年份：2025

卷号：16

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-85219386164);WOS:【SCI-EXPANDED(收录号:WOS:001434751800001)】；

基金：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by funding from the University Teachers Innovation Fund Project of Department of education of Gansu Province in 2024 (No.2024A-084), National Natural Science Foundation (No. 82260859), Lanzhou Science and Technology Bureau (No.2023-ZD-2), Gansu Medical Products Administration (No.2022GSMPA005), National Natural Science Foundation Regional Innovation Development Joint Fund Key Project (No. U23A20502).

语种：英文

外文关键词：muscone; COPD; interleukin-38; cigarette smoke; lipopolysaccharide

摘要：Background Muscone, a key component of musk, exhibits anti-inflammatory properties. However, its therapeutic potential in inflammatory lung diseases, such as chronic obstructive pulmonary disease (COPD), remains largely unexplored. This study aimed to investigate whether Muscone could exert a protective effect in a mouse model of COPD in vivo.Methods A COPD animal model was established by exposing mice to cigarette smoke (CS) and administering lipopolysaccharide (LPS) intranasally. After 4 weeks, mice were treated daily with dexamethasone (DEX) or different doses of Muscone for 3 weeks. Mouse body weight, lung function, and histopathology were determined. Serum levels of cytokines (IL-38, IL-1 beta, IL-17, TGF-beta, IFN-gamma) were measured using ELISA and qRT-PCR. Lung expression of CXCR3, IFN-gamma, IL-17A, and ROR gamma t was assessed by immunofluorescence.Results The body weight of COPD mice was significantly lower than that of Muscone-treated COPD mice, consistent with decreased lung function, accompanied by reduced circulating and lung IL-38 levels. After Muscone administration, lung function was significantly improved, accompanied by upregulation of circulating and lung anti-inflammatory cytokines, including IL-38, in a dose-dependent manner, while the expression of pro-inflammatory cytokines was significantly reduced. Additionally, Muscone significantly inhibited the protein expression of CXCR3, IFN-gamma, IL-17A, and ROR gamma t in lung tissues of COPD mice.Conclusion This study demonstrates that Muscone improves lung function in mice with COPD, potentially through a mechanism that may involve the modulation of cytokine expression, including the potential upregulation of anti-inflammatory cytokines such as IL-38. The precise underlying mechanisms of Muscone's therapeutic effects in COPD remain to be fully elucidated. Further research is needed to investigate the correlation between COPD lung pathophysiology and the specific effects of Muscone treatment, including a more detailed analysis of the balance between pro- and anti-inflammatory mediators in COPD animal models, particularly utilizing IL-38 GKO mice to further investigate the role of IL-38 in mediating the therapeutic effects of Muscone.