文献类型：期刊文献

英文题名：Convenient Synthesis, Antioxidant and Anti-Hypoxia Activities of 8-Hydroxy, 3′-Hydroxy, and 8,3′-Dihydroxydaidzein from Daidzein

作者：Zhang, Jie[1,2];Shao, Jin[3];Da, Qing-Yue[1,3];Ma, Hui-Ping[3];Jing, Lin-Lin[1]

第一作者：张建;Zhang, Jie

通信作者：Jing, LL[1]

机构：[1]Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Pharm, Xian 710061, Shaanxi, Peoples R China;[2]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Gansu, Peoples R China;[3]940th Hosp Joint Logist Support force PLA, Dept Pharm, Lanzhou 730050, Gansu, Peoples R China

第一机构：Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Pharm, Xian 710061, Shaanxi, Peoples R China

通信机构：[1]corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Pharm, Xian 710061, Shaanxi, Peoples R China.

年份：2023

卷号：59

期号：3

起止页码：444

外文期刊名：CHEMISTRY OF NATURAL COMPOUNDS

收录：;Scopus(收录号：2-s2.0-85161288888);WOS:【SCI-EXPANDED(收录号:WOS:001004124900004)，CCR-EXPANDED(收录号:WOS:001004124900004)】；

基金：AcknowledgmentThis study was supported by grants from the National Natural Science Foundation of China (Grant Nos. 81872796, 81202458, and 81571847).

语种：英文

外文关键词：daidzein; hydroxydaidzein; synthesis; antioxidant; anti-hypoxia activity

摘要：A convergent synthesis route to 8-hydroxydaidzein (8-HD), 3 '-hydroxydaidzein (3 '-HD), and 8,3 '-dihydroxydaidzein (8,3 '-DHD) starting from commercially available and inexpensive daidzein was reported. The product structures were characterized by FTIR, NMR, and MS analysis. The results of DPPH radical scavenging assay and reducing power assay indicated that 8,3 '-DHD, 8-HD, and 3 '-HD had excellent antioxidant activity. In addition, they exhibited good protective effects on the injured PC12 cells induced by hypoxia.