文献类型：期刊文献

英文题名：A young woman presenting with dyspnoea and diffuse T-wave inversions: a case report

作者：Dong, Wenjie[1,2];Zhang, Jingwen[2,3];Cao, Yunshan[3,4]

第一作者：Dong, Wenjie

通信作者：Cao, YS[1];Cao, YS[2]

机构：[1]First Peoples Hosp Tianshui, Dept Cardiol, 105 Jianshe Rd, Tianshui 741000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[3]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Heart Lung & Vessels Ctr, 32 West Second Sect First Ring Rd, Chengdu 610072, Sichuan, Peoples R China;[4]Gansu Prov Hosp, Pulm Vasc Dis Ctr, Dept Cardiol, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China

第一机构：First Peoples Hosp Tianshui, Dept Cardiol, 105 Jianshe Rd, Tianshui 741000, Gansu, Peoples R China

通信机构：[1]corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Heart Lung & Vessels Ctr, 32 West Second Sect First Ring Rd, Chengdu 610072, Sichuan, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Pulm Vasc Dis Ctr, Dept Cardiol, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2024

卷号：8

期号：7

外文期刊名：EUROPEAN HEART JOURNAL-CASE REPORTS

收录：Scopus(收录号：2-s2.0-85200120711);WOS:【ESCI(收录号:WOS:001280620500002)】；

基金：This work was supported by the National Natural Science Foundation of China (no. 82070052) and the Joint Funds of the Natural Science Foundation of Gansu Province (no. 23JRRA1544) granted to Y.C. DAS:The data underlying this article are available in the article and in its online Supplementary material.

语种：英文

外文关键词：Pulmonary hypertension WHO group 4; Takayasu arteritis; Inverted T-wave; Pulmonary artery stenosis; Case report

摘要：Background T-wave inversions on electrocardiograms (ECGs) indicate a variety of conditions, such as coronary artery disease, myocarditis, and cardiomyopathy. Pulmonary artery stenosis (PAS) and pulmonary hypertension (PH) may cause right ventricular enlargement and ischaemia, which are reflected as T-wave inversions on ECGs. Continuous ECG monitoring is crucial for detecting dynamic changes indicative of PAS progression and reversal in right heart remodelling. Case summary This report presents the case of a young woman who experienced exertional dyspnoea for 5 years with ECG findings showing T-wave inversions across multiple leads. The patient was diagnosed with PAS and PH caused by Takayasu arteritis (TA). Following three successful balloon pulmonary angioplasty sessions, the patient exhibited significant clinical improvement, including the remission of PAS and PH. Throughout a 59-month cumulative follow-up period, the sustained effectiveness of the treatment was evidenced by the regression of right heart remodelling, as manifested in the normalization of the initially inverted T-waves on the ECG. Discussion Electrocardiogram changes, including right axis deviation, right bundle branch block, a deep S wave in lead I (R/S < 1), and a prominent R wave in lead aVR (R/Q > 1), have been termed PAS syndrome, often linked to TA-associated PAS, especially in young East Asian females. Early diagnosis is crucial but challenging due to atypical symptoms. The non-invasive ECG is vital for detection, with balloon pulmonary angioplasty serving as an effective treatment for TA-induced PAS when surgery is not an option, improving outcomes and potentially reversing right heart remodelling.