文献类型：期刊文献

英文题名：The role of autophagy in cardiovascular disease: Cross-interference of signaling pathways and underlying therapeutic targets

作者：Jiang, Bing[1];Zhou, Xuan[2];Yang, Tao[3];Wang, Linlin[2];Feng, Longfei[3];Wang, Zheng[1];Xu, Jin[4];Jing, Weiyao[5];Wang, Tao[6];Su, Haixiang[6];Yang, GuoWei[7];Zhang, Zheng[1,7]

第一作者：Jiang, Bing

通信作者：Zhang, Z[1];Zhang, Z[2]

机构：[1]Gansu Univ Tradit Chinese Med, Dept Integrated Chinese & Western Med, Lanzhou, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Dept Clin Med 1, Lanzhou, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Dept Basic Med, Lanzhou, Peoples R China;[4]Lanzhou Univ, Dept Clin Med 1, Lanzhou, Peoples R China;[5]Gansu Univ Tradit Chinese Med, Dept Acupuncture Moxibust & Tuina, Lanzhou, Peoples R China;[6]Gansu Prov Canc Hosp, Gansu Prov Acad Inst Med Res, Res Ctr Translat Med, Lanzhou, Peoples R China;[7]First Hosp Lanzhou Univ, Ctr Heart, Lanzhou, Peoples R China

第一机构：甘肃中医药大学中西医结合学院

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Dept Integrated Chinese & Western Med, Lanzhou, Peoples R China;[2]corresponding author), First Hosp Lanzhou Univ, Ctr Heart, Lanzhou, Peoples R China.|[10735ed249c6606940a33]甘肃中医药大学中西医结合学院;[10735]甘肃中医药大学;

年份：2023

卷号：10

外文期刊名：FRONTIERS IN CARDIOVASCULAR MEDICINE

收录：;Scopus(收录号：2-s2.0-85152664708);WOS:【SCI-EXPANDED(收录号:WOS:000967190500001)】；

基金：Funding The research was in part supported by research grants from National Natural Science Foundation of China (No. 82060807) and Natural Fund project of Gansu Province (No. 18JR2FA005).

语种：英文

外文关键词：autophagy; cardiovascular disease; autophagy-related gene; signaling pathway; crosstalk; potential target

摘要：Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic proteins and organelles, which realizes the metabolic needs of cells and the renewal of organelles. Autophagy-related genes (ATGs) are the main molecular mechanisms controlling autophagy, and their functions can coordinate the whole autophagic process. Autophagy can also play a role in cardiovascular disease through several key signaling pathways, including PI3K/Akt/mTOR, IGF/EGF, AMPK/mTOR, MAPKs, p53, Nrf2/p62, Wnt/beta-catenin and NF-kappa B pathways. In this paper, we reviewed the signaling pathway of cross-interference between autophagy and cardiovascular diseases, and analyzed the development status of novel cardiovascular disease treatment by targeting the core molecular mechanism of autophagy as well as the critical signaling pathway. Induction or inhibition of autophagy through molecular mechanisms and signaling pathways can provide therapeutic benefits for patients. Meanwhile, we hope to provide a unique insight into cardiovascular treatment strategies by understanding the molecular mechanism and signaling pathway of crosstalk between autophagy and cardiovascular diseases.