文献类型：期刊文献

英文题名：U-shaped association between triglyceride/HDL ratio and all-cause mortality in obese sepsis patients: A retrospective study based on eICU database

作者：Wu, Yaozhou[1,2];Sun, Yingying[1,4];Wang, Ruirui[4];Liu, Qianqian[1];Wang, Wenjie[1];Guo, Rubing[4];Zhao, Wei[3];Wei, Lianhua[1,2]

第一作者：Wu, Yaozhou

通信作者：Wei, LH[1];Wei, LH[2];Zhao, W[3]

机构：[1]Gansu Prov Hosp, Dept Clin Lab, Lanzhou 730000, Peoples R China;[2]Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Peoples R China;[3]China Japan Friendship Hosp, Dept Clin Lab, 2 Yinghuayuan East St, Beijing 100029, Peoples R China;[4]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Peoples R China

第一机构：Gansu Prov Hosp, Dept Clin Lab, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Clin Lab, Lanzhou 730000, Peoples R China;[2]corresponding author), Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Peoples R China;[3]corresponding author), China Japan Friendship Hosp, Dept Clin Lab, 2 Yinghuayuan East St, Beijing 100029, Peoples R China.

年份：2026

卷号：50

期号：6

外文期刊名：MEDICINA INTENSIVA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001787878400001)】；

基金：This study was supported by the Hospital Fund of Gansu Provincial (No. 24GSSYD-3), Doctoral supervisor cultivation project at Gansu Provincial Hospital (No. 22GSSYA-2) and General Project of Joint Research Fund (No. 25JRRA1210). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

语种：英文

外文关键词：TG/HDL; Obese sepsis; All-cause mortality; U-shaped curve; Prognostic assessment

摘要：Objective: This study explored the link between the TG/HDL ratio and mortality in obese sepsis patients using the eICU database. Design: Retrospective observational study. Setting: Intensive Care Medicine. Patients: According to Sepsis 3.0 criteria, sepsis is diagnosed with infection and a SOFA score >= 2. This study included adults (age >= 18) with ICU stays >= 48 h to ensure data stability. Patients with diabetes, acute pancreatitis, or those on lipid-lowering or antidiabetic treatments were excluded due to their impact on lipid and glucose metabolism, which could bias the analysis of the TG/HDL ratio and all-cause mortality. Interventions: 938 obese sepsis patients were selected, and statistical methods (variable assessment, difference test, regression model, curve fitting, subgroup analysis) were used. The study was carried out using R 4.3.2 software. Main variables of interest: TG/HDL. Results: The TG/HDL ratio varied across quartiles and was significantly linked to mortality in obese sepsis patients. Regression and curve fitting showed a U-shaped relationship for TG/HDL < 8, with an inflection point at 3.59. The K-M curve confirmed this U-shaped pattern, and subgroup analysis revealed a significant interaction with hypertension. Conclusions: A U-shaped relationship exists between TG/HDL and mortality in obese sepsis patients, with both low and high levels increasing death risk. (c) 2025 Elsevier Espana, S.L.U. y SEMICYUC. All rights are reserved, including those for text and data mining, AI training, and similar technologies.