文献类型：期刊文献

英文题名：Enterochromaffin cell hyperplasia in the gut: Factors, mechanism and therapeutic clues

作者：Qin, Hong-yan[1];Wong, Hoi Leong Xavier[2];Zang, Kai-hong[3];Li, Xun[4,5];Bian, Zhao-xiang[2]

第一作者：Qin, Hong-yan

通信作者：Bian, ZX[1];Li, X[2]

机构：[1]Lanzhou Univ, Hosp 1, Dept Pharm, Lanzhou, Gansu, Peoples R China;[2]Hong Kong Baptist Univ, IBAG, Ctr Clin Res Chinese Med, Sch Chinese Med,Kowloon Tong, Hong Kong, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Coll Pharm, Lanzhou, Gansu, Peoples R China;[4]Lanzhou Univ, Hosp 1, Dept Gen Surg 5, Lanzhou, Gansu, Peoples R China;[5]Key Lab Biotherapy & Regenerat Med Gansu Prov, Lanzhou, Gansu, Peoples R China

第一机构：Lanzhou Univ, Hosp 1, Dept Pharm, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Hong Kong Baptist Univ, IBAG, Ctr Clin Res Chinese Med, Sch Chinese Med,Kowloon Tong, Hong Kong, Peoples R China;[2]corresponding author), Lanzhou Univ, Hosp 1, Dept Gen Surg 5, Key Lab Biotherapy & Regenerat Med Gansu Prov, Lanzhou, Gansu, Peoples R China.

年份：2019

卷号：239

外文期刊名：LIFE SCIENCES

收录：;Scopus(收录号：2-s2.0-85074589296);WOS:【SCI-EXPANDED(收录号:WOS:000501363000021)】；

基金：This work was supported by the National Science Foundation of China (81341145, 81400596), and the Fundamental Research Funds for the Central Universities (lzujbky-2014-223, lzujbky-2015-38).

语种：英文

外文关键词：Enterochromaffin cell; Hyperplasia; Early-life stress; Inflammation; Infection

摘要：Enterochromaffin (EC) cell is the main cell type that responsible for 5-hydroxytryptamine (5-HT) synthesis, storage and release of the gut. Intestinal 5-HT play a key role in visceral sensation, intestinal motility and permeability, EC cell hyperplasia and increased 5-HT bioavailability in the gut have been found to be involved in the symptoms generation of irritable bowel syndrome and inflammatory bowel disease. EC cells originate from intestinal stem cells, the interaction between proliferation and differentiation signals on intestinal stem cells enable EC cell number to be regulated in a normal level. This review focuses on the impact factors, pathogenesis mechanisms, and therapeutic clues for intestinal EC cells hyperplasia, and showed that EC cell hyperplasia was observed under the condition of physiological stress, intestinal infection or intestinal inflammation, the disordered proliferation and/or differentiation of intestinal stem cells as well as their progenitor cells all contribute to the pathogenesis of intestinal EC cell hyperplasia. The altered intestinal niche, i.e. increased corticotrophin releasing factor (CRF) signal, elevated nerve growth factor (NGF) signal, and Th2-dominant cytokines production, has been found to have close correlation with intestinal EC cell hyperplasia. Currently, CRF receptor antagonist, nuclear factor-kappa B inhibitor, and NGF receptor neutralizing antibody have been proved useful to attenuate intestinal EC cell hyperplasia, which may provide a promising clue for the therapeutic strategy in EC cell hyperplasia related diseases.