文献类型：期刊文献

中文题名：甘草有效成分及复方治疗溃疡性结肠炎的研究进展

英文题名：Active Components and Compound Prescriptions of Glycyrrhizae Radix et Rhizoma in Treatment of Ulcerative Colitis:A Review

作者：高广淼[1];杨玲玲[1];杨秀娟[1];殷亭湄[1];杨必乾[1];连小龙[2];付晓艳[1];李洁[1];马趣环[1,3];邓毅[1,4];杨志军[1]

第一作者：高广淼

机构：[1]甘肃中医药大学药学院,兰州730000;[2]青海大学,西宁810016;[3]甘肃省医学科学研究院,兰州730050;[4]甘肃省中药药理与毒理学重点实验室,兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2023

卷号：29

期号：23

起止页码：264

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金地区基金项目(81960723);甘肃省自然科学基金项目(21JR111RA145,22JR11RA112);甘肃省教育科技创新基金项目(2023A-082);甘肃省中医药管理局项目(GZKP-2022-37);兰州市科技计划项目(2022-3-21);甘肃省科技计划项目(22JR5RA577);甘肃省中药炮制技术传承基地项目。

语种：中文

中文关键词：甘草;甘草有效成分;溃疡性结肠炎;甘草复方;研究进展

外文关键词：Glycyrrhizae Radix et Rhizoma;active ingredients of Glycyrrhizae Radix et Rhizoma;ulcerative colitis;compound prescriptions containing Glycyrrhizae Radix et Rhizoma;research progress

摘要：溃疡性结肠炎(UC)是一种慢性的、复发性的炎症性肠道疾病,主要累及结肠黏膜。UC的主要症状包括腹泻、腹痛、里急后重及黏液和血便等,严重时还可能伴随营养不良和全身症状,发病率也不断攀升,给患者的健康和生活质量带来了显著的影响。UC发病机制尚不明确,目前西医治疗多使用柳氮磺吡啶、糖皮质激素类、免疫抑制剂等为主,但其不良反应较多,治疗效果不理想。中药安全性高,且不良反应较少,以其多成分、多靶点、多通路发挥药效受到广大学者的重视。故从中药中寻找治疗UC的药物已成为一大热点。甘草为我国传统中药材,是临床上应用较广的传统中药之一,具有补脾益气、清热解毒、祛痰止咳、缓急止痛、调和诸药之功效。甘草主要含有甘草酸、甘草次酸、甘草酸二铵等活性成分。现代药理学研究表明,甘草具有抗炎、抗氧化、抗菌、免疫调节等多种药理作用。有研究统计在治疗UC的中药中,甘草位居前三。近年来,中药甘草及复方治疗UC也取得了一定进展。基于此,通过对甘草主要化学成分如甘草酸、甘草酸二铵、甘草多糖、甘草次酸和异甘草素及甘草相关复方的抗炎、调节免疫、调节肠道菌群、调控细胞凋亡和降低氧化应激等作用机制进行分析总结,为甘草进一步开发及临床应用提供依据。
Ulcerative colitis(UC)is a chronic recurrent inflammatory bowel disease which primarily affects the colonic mucosa.The UC patients mainly present diarrhea,abdominal pain,tenesmus,and mucous bloody stools,and even malnutrition and systemic symptoms in severe cases,with rising incidence,which has a significant impact on the health and quality of life of patients.The pathogenesis of UC is not clear,and the Western medical therapies include sulfasalazine,glucocorticoids,and immunosuppressants,which,however,have side effects and unsatisfactory effects.Chinese medicine with high safety,mild adverse reactions,and a multi-component,multi-target,and multi-pathway treatment manner has garnering increasing attention.Therefore,finding the Chinese medicine to treat UC has become a hot spot.Glycyrrhizae Radix et Rhizoma is one of the commonly used Chinese herbal medicines,with the effects of tonifying spleen and reinforcing qi,clearing heat and detoxifying,dispelling phlegm and relieving cough,relieving pain,and harmonizing medicines.Glycyrrhizae Radix et Rhizoma mainly contains glycyrrhizic acid,glycyrrhetinic acid,diammonium glycyrrhizinate and other active ingredients.Modern pharmacological studies have shown that Glycyrrhizae Radix et Rhizoma has anti-inflammatory,antioxidant,antimicrobial,and immunomodulatory activities.According to statistics,Glycyrrhizae Radix et Rhizoma is among the top three Chinese herbal medicines for the treatment of UC.The recent years have witnessed progress in the treatment of UC with Glycyrrhizae Radix et Rhizoma and the related prescriptions.The present study summarized the mechanisms underlying the antiinflammatory,immunomodulatory,intestinal flora-regulating,cell apoptosis-inducing,and oxidative stressreducing effects of the key chemical constituents(glycyrrhetinic acid,diammonium glycyrrhizinate,polysaccharide,glycyrrhetinic acid,and isoglycyrrhizin)and compound prescriptions of Glycyrrhizae Radix et Rhizoma.The findings provide a solid foundation for further development and clinical application of Glycyrrhizae Radix et Rhizoma.