文献类型：期刊文献

英文题名：The impact of transcranial magnetic stimulation on serum thyroid-stimulating hormone levels in depressive patients: a systematic review and meta-analysis of randomized controlled trials

作者：Ma, Yutai[1,2];Wei, Chunyan[2];Pan, Qiao[1,2];Wang, Yali[1]

第一作者：Ma, Yutai

通信作者：Wei, CY[1]

机构：[1]Gansu Univ Chinese Med, Sch Hlth Management, Lanzhou, Peoples R China;[2]Third Peoples Hosp Lanzhou, Dept Psychol, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Third Peoples Hosp Lanzhou, Dept Psychol, Lanzhou, Peoples R China.

年份：2026

卷号：17

外文期刊名：FRONTIERS IN PSYCHIATRY

收录：;WOS:【SSCI(收录号:WOS:001684685800001)，SCI-EXPANDED(收录号:WOS:001684685800001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by the Science and Technology Plan Project of Gansu Province, China (22JR5RA1067) and the Health Industry Research Project of Lanzhou, China (A2024021).

语种：英文

外文关键词：depression; meta-analysis; randomized controlled trials; thyroid-stimulating hormone; transcranial magnetic stimulation

摘要：Introduction The findings of current research on the impact of transcranial magnetic stimulation (TMS) on thyroid function are inconsistent. This study investigated the effects of TMS on the function of the hypothalamic-pituitary-thyroid axis (HPT axis) in patients with depression through meta-analysis, with a focus on the thyroid-stimulating hormone (TSH). Methods From inception to November 27, 2025, we conducted a systematic search of randomized controlled trials investigating TMS therapy for depression across PubMed, Embase, Web of Science, the Cochrane Library, and Chinese biomedical databases. Two independent reviewers screened the retrieved abstracts and full-text articles using our predefined search strategy, in duplicate, to assess eligibility criteria, extract data, and evaluate the risk of bias. Due to the high heterogeneity, a random-effects model was selected. The review protocol was prospectively registered in PROSPERO (CRD420251006441). Results Meta-analyses of the 5 randomized controlled trials included demonstrated that TMS treatment had no statistically significant effect on TSH levels in depressed patients (Z = 0.06, P = 0.952). Sensitivity analyses and publication bias tests(Egger's regression test, t = 1.01, P < 0.386) supported the robustness of the results. TSH levels in postpartum depressed patients were also not statistically significantly modulated by TMS (Z = 1.71, P = 0.087), but the results were not robust. Discussion This meta-analysis indicates that TMS exerts no statistically significant influence on TSH concentrations in individuals with depression, implying a negligible effect on the HPT axis. However, it is important to emphasize that this constitutes only initial preliminary evidence. Although the findings are consistent across the depressive cohort, the data about postpartum depression remain inconclusive, highlighting the necessity for additional investigation. These results enhance our understanding of TMS's neuroendocrine mechanisms within the context of depressive disorder.