文献类型：期刊文献

英文题名：Microbial metabolites in tumor epigenetic regulation

作者：Zhang, Wangzheqi[1,2];Zhang, Haoling[3];Liao, Yan[1,2];Jiang, Shuya[4];Zhang, Haolong[5];Huang, Chenwei[6];Song, Zhijing[7];Zhao, Rui[7];Lu, Ping[8];Kang, Xiaohong[5];Kong, Eryan[9];Zhu, Yalin[10];Wang, Wei[7];Liu, Xuesong[11];Chen, Yisheng[12,13];Luo, Zhiwen[14];Li, Zhaoyu[7];Wang, Di[3];Xing, Na[15];Guo, Yadong[16];Zhang, Jingjing[17,18,19];Wang, Xiaojing[20];Wang, Wenyi[21];Adam, Mowaffaq[22];Shaharuddin, Bakiah[3];Musa, Muhamad Yusri[23];Sandai, Doblin[3];Zhu, Chenglong[1,2];Jiang, Aimin[24,25];Luo, Peng[26,27];Zhao, Zhijie[28];Zou, Zui[1,2]

第一作者：Zhang, Wangzheqi

通信作者：Zhu, CL[1];Zou, Z[1];Sandai, D[2];Jiang, AM[3];Luo, P[4];Zhao, ZJ[5]

机构：[1]Naval Med Univ, Changhai Hosp, Dept Anesthesiol, Shanghai 200433, Peoples R China;[2]Naval Med Univ, Sch Anesthesiol, Shanghai, Peoples R China;[3]Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, George Town 13200, Malaysia;[4]Naval Med Univ, Affiliated Hosp 3, Dept Hepat Surg 3, Shanghai, Peoples R China;[5]Henan Med Univ, Affiliated Hosp 1, Weihui, Peoples R China;[6]Naval Med Univ, Fac Psychol, Shanghai, Peoples R China;[7]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[8]Henan Med Univ, Affiliated Hosp 1, Dept Oncol, Weihui, Peoples R China;[9]Xinxiang Med Univ, Affiliated Hosp 1, Weihui, Peoples R China;[10]Eastern Theater Command Naval Hosp, Dept Anesthesiol, Zhoushan, Peoples R China;[11]Gansu Univ Chinese Med, Basic Med Coll, Lanzhou, Peoples R China;[12]Fujian Med Univ, Fuzhou, Peoples R China;[13]Ningde Normal Univ, Med Coll, Fujian Key Lab Toxicant & Drug Toxicol, Ningde, Peoples R China;[14]Fudan Univ, Huashan Hosp, Dept Sports Med, Shanghai, Peoples R China;[15]Zhengzhou Univ, Affiliated Hosp 1, Dept Anesthesiol Pain & Perioperat Med, Zhengzhou, Peoples R China;[16]Tongji Univ, Shanghai Peoples Hosp 10, Dept Urol, Shanghai, Peoples R China;[17]Chinese Acad Med Sci, Fuwai Yunnan Hosp, Kunming, Peoples R China;[18]Yunnan Prov Cardiovasc Clin Med Ctr, Kunming, Peoples R China;[19]Yunnan Prov Cardiovasc Clin Med Res Ctr, Kunming, Peoples R China;[20]Shanghai Jiao Tong Univ, Tongren Hosp, Sch Med, Dept Rheumatol & Immunol, Shanghai, Peoples R China;[21]Juntendo Univ, Tokyo, Japan;[22]SUNY Old Westbury, Long Isl City, NY USA;[23]Univ Sains Malaysia, Adv Med & Dent Inst, Dept Clin Med, George Town, Malaysia;[24]Naval Med Univ, Changhai Hosp, Dept Urol, Shanghai 200433, Peoples R China;[25]First Naval Hosp Southern Theater Command, Dept Urol, Zhanjiang, Peoples R China;[26]Southern Med Univ, Zhujiang Hosp, Dept Oncol, Guangzhou 510282, Peoples R China;[27]Nanjing Med Univ, Donghai Cty Peoples Hosp, Kangda Coll, Lianyungang, Peoples R China;[28]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Shanghai 200011, Peoples R China

第一机构：Naval Med Univ, Changhai Hosp, Dept Anesthesiol, Shanghai 200433, Peoples R China

通信机构：[1]corresponding author), Naval Med Univ, Changhai Hosp, Dept Anesthesiol, Shanghai 200433, Peoples R China;[2]corresponding author), Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, George Town 13200, Malaysia;[3]corresponding author), Naval Med Univ, Changhai Hosp, Dept Urol, Shanghai 200433, Peoples R China;[4]corresponding author), Southern Med Univ, Zhujiang Hosp, Dept Oncol, Guangzhou 510282, Peoples R China;[5]corresponding author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Shanghai 200011, Peoples R China.

年份：2026

卷号：5

期号：1

外文期刊名：IMETA

收录：;Scopus(收录号：2-s2.0-105032895376);WOS:【SCI-EXPANDED(收录号:WOS:001713235200001)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 82572494), Shanghai Industrial Collaborative Innovation Project (Nos. HCXBCY-2023-041, HCXBCY-2024-033, XTCX-KJ-2024-39), Shanghai Oriental Talents Program (Outstanding Talents Project), 2024 Medical Technology Key Research Project of the Chinese Medical Education Association (No. 2024KTZ011), 2024 Basic Medicine Innovation Open Project of Naval Medical University (supported by National Key Laboratory of Immunity and Inflammation, No. JCKFKT-MS-002), Gansu Provincial Science and Technology Program-Key Research and Development Program (International Science and Technology Cooperation Category), Project No. 23YFWA0005; Gansu Provincial University Innovation Fund (No. 2025A-110); Collaborative Innovation Center for Traditional Chinese Medicine Prevention and Control of Nutrition-and Environment-Related Diseases in Northwest China (No. ZYX-24-02); Gansu Provincial Department of Science and Technology, Natural Science Foundation (No. 22JR5RA582); Gansu Provincial Department of Science and Technology, Natural Science Foundation (No. 2023A-088).

语种：英文

外文关键词：bidirectional feedback loop; epigenetic modulation; microbial metabolites; precision oncology; tumor epigenetics; tumor microenvironment

摘要：With an increasing global cancer burden, the regulatory function of the human microbiome and its metabolites in tumor epigenetics has garnered significant interest. Microbial metabolites are not merely passive byproducts but serve as signaling molecules and epigenetic modulators, contributing to tumor progression through multiple overlapping pathways. Short-chain fatty acids (SCFAs) such as butyrate directly inhibit histone deacetylases to reactivate tumor suppressor genes, while secondary bile acids (BAs) induce gene silencing via DNA methylation remodeling by altering the FXR/TGR5 signaling pathway. Folate and vitamin B12 serve as substrates for DNA and histone methylation through one-carbon metabolism. A complex bidirectional feedback loop exists between microbial metabolism and tumor epigenetics: reprogramming driven by hypoxia or oncogenes alters metabolite flux, generating molecules such as lactate and succinate that not only remodel chromatin and the tumor microenvironment (TME) but also selectively promote the growth of metabolically adapted microbial species, thereby reinforcing epigenetic dysregulation. Despite growing mechanistic insights, establishing causality and correlating spatiotemporal dynamics and dose responses within the highly heterogeneous TME remain major challenges. Data integration across multi-omics remains limited by methodological and computational constraints. Resolving these issues will be critical for understanding the microbe-metabolite-epigenetic axis and advancing personalized precision oncology.