文献类型：期刊文献

英文题名：Comparing the diagnostic efficacy of [¹⁸F]FDG PET/CT and [¹⁸F]FDG PET/MRI in breast cancer recurrence: a systematic review and meta-analysis

作者：Liu, Shiqing[1,2];Xie, Yu[1];Ding, Wei[3];Ma, Xiaopeng[4];Li, Zhilin[1];Zhang, Lei[5];Zhang, Ya[1];Ai, Conghui[1]

第一作者：刘世琼;刘思强;刘世强;Liu, Shiqing

通信作者：Zhang, Y[1];Ai, CH[1];Zhang, L[2]

机构：[1]Kunming Med Univ, Yunnan Canc Hosp, Yunnan Canc Ctr, Dept Radiol,Affiliated Hosp 3, Kunming, Yunnan, Peoples R China;[2]Gansu Univ Chinese Med, Coll Clin Med 1, Lanzhou, Gansu, Peoples R China;[3]920th Hosp Joint Logist Support Force, Kunming, Yunnan, Peoples R China;[4]Hebei Med Univ, Hosp 2, Shijiazhuang, Hebei, Peoples R China;[5]Kunming Med Univ, Yunnan Canc Hosp, Yunnan Canc Ctr, Dept Gynecol,Affiliated Hosp 3, Kunming, Yunnan, Peoples R China

第一机构：Kunming Med Univ, Yunnan Canc Hosp, Yunnan Canc Ctr, Dept Radiol,Affiliated Hosp 3, Kunming, Yunnan, Peoples R China

通信机构：[1]corresponding author), Kunming Med Univ, Yunnan Canc Hosp, Yunnan Canc Ctr, Dept Radiol,Affiliated Hosp 3, Kunming, Yunnan, Peoples R China;[2]corresponding author), Kunming Med Univ, Yunnan Canc Hosp, Yunnan Canc Ctr, Dept Gynecol,Affiliated Hosp 3, Kunming, Yunnan, Peoples R China.

年份：2025

卷号：12

外文期刊名：FRONTIERS IN MEDICINE

收录：;Scopus(收录号：2-s2.0-105013631289);WOS:【SCI-EXPANDED(收录号:WOS:001551460700001)】；

基金：The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by the National Natural Science Foundation of China (NO. 82160524); Yunnan Fundamental Research Kunming Medical University Projects (grant NO. 202501AY070001-110); Yunnan Fundamental Research Projects (202401AT070006); and Major Science and Technology Projects in Yunnan Province (202201AY070001-148); Yunnan Provincial Health Commission's Training Program for Medical Discipline Leaders (D-2024012); the Applied Basic Research Foundation of Yunnan Province Science and Technology Department (NO. 202301AT070246).

语种：英文

外文关键词：breast cancer; [F-18]FDG PET/CT; [F-18]FDG PET/MRI; recurrence; meta-analysis

摘要：Purpose: This meta-analysis evaluates and compares the diagnostic accuracy of [F-18]FDG PET/CT and [F-18]FDG PET/MRI in detecting breast cancer recurrence. Methods: A search was conducted across PubMed, Web of Science, and Embase databases up to June 10, 2025, to identify studies evaluating the diagnostic performance of [F-18]FDG PET/CT and/or [F-18]FDG PET/MRI in breast cancer recurrence. Sensitivity and specificity were calculated using the DerSimonian and Laird method with Freeman-Tukey double arcsine transformation. The Quality Assessment for Studies of Diagnostic Accuracy-2 (QUADAS-2) guidelines were employed to perform the quality evaluation. Results: Seventeen studies involving 1,450 patients were included. At the lesion level, the sensitivity of [F-18]FDG PET/CT was 0.97 (95% CI: 0.91-1.00), with a specificity of 0.79 (95% CI: 0.58-0.94). [F-18]FDG PET/MRI showed a sensitivity of 0.95 (95% CI: 0.91-0.99) and specificity of 0.87 (95% CI:0.75-0.95). Both modalities demonstrated similar sensitivity (p = 0.71) and specificity (p = 0.66). At the patient level, the sensitivity of [F-18]FDG PET/CT was 0.93 (95% CI: 0.88-0.96), with a specificity of 0.87 (95% CI: 0.80-0.93). [F-18]FDG PET/MRI showed a sensitivity of 0.99 (95% CI: 0.94-1.00) and specificity of 0.98 (95% CI, 0.90-1.00). Both modalities demonstrated similar sensitivity (p = 0.07) and specificity (p = 0.06). Conclusion: [F-18]FDG PET/CT and [F-18]FDG PET/MRI exhibit comparable sensitivity and specificity in detecting breast cancer recurrence at both the lesion and patient levels. However, high heterogeneity warrants further head-to-head studies to strengthen the evidence and provide more comprehensive insights.