文献类型：期刊文献

英文题名：Associations of homocysteine status and homocysteine metabolism enzyme polymorphisms with hypertension and dyslipidemia in a Chinese hypertensive population

作者：Yuan, Xiaojie[1];Wang, Tingcai[2];Gao, Jie[1];Wang, Yunchao[3];Chen, Yajun[3];Kaliannan, Kanakaraju[4,5];Li, Xiaochun[6];Xiao, Jing[6];Ma, Tianyou[7];Zhang, Lei[1];Shao, Zhongjun[1]

第一作者：Yuan, Xiaojie

通信作者：Zhang, L[1];Shao, ZJ[1];Ma, TY[2]

机构：[1]Air Force Med Univ, Sch Publ Hlth, Dept Epidemiol, 17 Changle West RD, Xian 710032, Shaanxi, Peoples R China;[2]Gansu Prov Ctr Dis Control & Prevent, Dept Chron Dis control, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;[4]Massachusetts Gen Hosp, Dept Med, Lab Lipid Med & Technol, Boston, MA 02114 USA;[5]Harvard Med Sch, Boston, MA 02115 USA;[6]Ctr Dis Control Wuwei, Dept Chron Dis Control, Wuwei, Gansu, Peoples R China;[7]Xi An Jiao Tong Univ, Med Sch, Inst Endem Dis Environm & Diseases Related Gene, Key Lab,Educ Minisrt, 76 Yanta West RD, Xian 710061, Shaanxi, Peoples R China

第一机构：Air Force Med Univ, Sch Publ Hlth, Dept Epidemiol, 17 Changle West RD, Xian 710032, Shaanxi, Peoples R China

通信机构：[1]corresponding author), Air Force Med Univ, Sch Publ Hlth, Dept Epidemiol, 17 Changle West RD, Xian 710032, Shaanxi, Peoples R China;[2]corresponding author), Xi An Jiao Tong Univ, Med Sch, Inst Endem Dis Environm & Diseases Related Gene, Key Lab,Educ Minisrt, 76 Yanta West RD, Xian 710061, Shaanxi, Peoples R China.

年份：2020

卷号：42

期号：1

起止页码：52

外文期刊名：CLINICAL AND EXPERIMENTAL HYPERTENSION

收录：;Scopus(收录号：2-s2.0-85076320414);WOS:【SCI-EXPANDED(收录号:WOS:000534814300008)】；

基金：This work was supported by the National Natural Science Foundation of China under Grant [number 81373058 and 81370082]; China Special Grant for Prevention and Control of Infection Disease under Grant [number 2017ZX10105011]. Thanks for the support of Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment.

语种：英文

外文关键词：Homocysteine; blood pressure; serum lipids; single nucleotide polymorphisms; hypertension

摘要：Background: Hypertension (HTN), dyslipidemia and hyperhomocysteinemia (HHcy) are risk factors for cardiovascular disease (CVD). Methods: Hypertensive Chinese subjects (n = 228) were enrolled. MTHFR C667T, MTHFR A1298C, MTR A2756G, and MTRR A66G genotypes were determined. Unconditional logistic regression was performed to determine the associations of serum Hcy status and genotypes with HTN and dyslipidemia. Results: The mean age of hypertensive adults was 65.53 +/- 9.94 years, including 88 (38.6%) men and 140 (61.4%) women. Patients with MTHFR 667TT and MTRR GG carriers showed higher serum Hcy levels (P = 0.019 and 0.018, respectively), which is associated with higher serum triacylglycerols (TAG) and total cholesterol (TC) levels (P = 0.014 and 0.044, respectively) and a higher risk for hypertriglyceridemia (OR = 1.889, 95% CI: 1.105-3.229, P = 0.020). Compared with low Hcy and MTRR 66AA, those with high Hcy and 66AA or 66AG+GG showed higher odd\s of hypertriglyceridemia (MTRR 66AA+ high Hcy: OR: 2.692, 95% CI: 1.189-6.096, Pcombined = 0.018; MTRR 66AG/GG+ high Hcy: OR: 3.433, 95% CI: 1.517-7.772, Pcombined = 0.003, respectively). Patients with high Hcy and MTHFR 667CC, as well as those with low Hcy and 667CT+TT, showed lower odds of uncontrolled SBP (MTHFR 667CC+ high Hcy: OR: 0.338, 95% CI: 0.115-0.996, Pcombined = 0.049; MTHFR 667CT/TT+ low Hcy: OR: 0.421, 95% CI: 0.193-0.921, Pcombined = 0.030) compared to patients with low Hcy and MTHFR 667CC. Conclusions: Serum Hcy status and Hcy metabolism gene polymorphisms (MTHFR C667T and MTRR A66G) may have synergistic effects on the prevalence of HTN and dyslipidemia.