文献类型：期刊文献

英文题名：Aberrant static and dynamic functional connectivity within amygdala in type 2 diabetes patients with and without depression associated with neurotransmitter profiles: A multimodal imaging study

作者：Tian, Jing[1];Yang, Chen[1];Fan, Yan-Jun[2];Zhao, Yi-Wei[2];Zou, Quan[2];Li, Zhou-Le[1];Zhang, Hui-Yan[1];Liu, Rui-Fang[1];Cao, Jian-Cang[1];Huang, Gang[1];Zhao, Lian-Ping[1]

第一作者：Tian, Jing

通信作者：Zhao, LP[1]

机构：[1]Gansu Prov Hosp, Dept Radiol, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China

第一机构：Gansu Prov Hosp, Dept Radiol, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Radiol, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2026

卷号：395

外文期刊名：JOURNAL OF AFFECTIVE DISORDERS

收录：;WOS:【SSCI(收录号:WOS:001625218600004)，SCI-EXPANDED(收录号:WOS:001625218600004)】；

基金：This project supported by the National Natural Science Foundation of China (No.82360343) ; the Natural Science Foundation of Gansu Province, China (No.25JRRA296) ; the Key Research and Development Program of Gansu Province, China (No.23YFFA0048) ; the Gansu Provincial Health Commission Scientific Research Project (No. GSWSQN2024-03) ; the Gansu Traditional Chinese Medicine Management Scientific Research Project (No.GZKP-2020-36) ; the Foundation of Gansu Provincial Hospital (Nos.2024KYQDJ-A-34, 24GSSYB-15) .

语种：英文

外文关键词：Diabetes mellitus; type 2; Amygdala; Dynamic functional connectivity; Static functional connections; Depression; Neurotransmitters

摘要：Background: Type 2 diabetes mellitus (T2DM) with depression patients exhibit poor treatment adherence and increased social burden. This multimodal neuroimaging study investigated amygdala subregional static/dynamic functional connectivity (sFC/dFC) and the association with neurotransmitter receptor/transporter distributions, to explore the underlying pathophysiological mechanisms of T2DM with depression. Methods: Demographic data, clinical characteristics, neuropsychological tests, and resting-state functional magnetic resonance imaging of 191 participants (49 depressed T2DM, 70 non-depressed T2DM, 72 healthy controls) were collected and evaluated. Fourteen amygdala subregions were analyzed for sFC/dFC, followed by correlation and receiver operating characteristic curve analysis. Then, we correlated the aberrant amygdala connectivity with neurotransmitter receptor/transporter maps. Results: Static analysis revealed abnormal amygdala FC with the middle frontal gyrus (MFG), middle cingulate, and middle occipital gyrus, patterns almost universally presented in dynamic analysis. Notably, the dynamic analysis highlighted more pronounced differences in FC between the left auxiliary basal or basomedial nucleus and the right MFG in the depressed T2DM group, and expanded connections disruptions, including the prefrontal cortex (MFG, medial superior frontal gyrus), ventral visual pathway (middle and inferior occipital gyrus, fusiform gyrus, middle temporal gyrus), anterior cingulate cortex, Crus II, and precuneus. Both sFC and dFC abnormalities exhibited high areas under receiver operating characteristic curve, with dFC being more significant. Moreover, aberrant amygdala connectivity was negatively correlated with spatial distribution of SERT and D2 receptor. Conclusions: These findings may provide new insights into the neuropathophysiological mechanisms of depression in T2DM.