文献类型：期刊文献

英文题名：Animal models of chronic obstructive pulmonary disease: a systematic review

作者：Feng, Tiantian[1];Cao, Juan[2];Ma, Xiaoting[3];Wang, Xinhua[1];Guo, Xiaolong[1];Yan, Na[1];Fan, Chunling[4];Bao, Shisan[1];Fan, Jingchun[1]

第一作者：Feng, Tiantian

通信作者：Bao, SS[1];Fan, JC[1];Fan, CL[2]

机构：[1]Gansu Univ Chinese Med, Sch Publ Hlth, Ctr Evidence Based Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Dept Publ Hlth, Affiliated Hosp, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Sch Nursing, Lanzhou, Peoples R China;[4]Gansu Prov Canc Hosp, Dept Clin Pharm, Lanzhou, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Publ Hlth, Ctr Evidence Based Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Canc Hosp, Dept Clin Pharm, Lanzhou, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2024

卷号：11

外文期刊名：FRONTIERS IN MEDICINE

收录：;Scopus(收录号：2-s2.0-85208635200);WOS:【SCI-EXPANDED(收录号:WOS:001349390000001)】；

基金：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by funding from the National Key R&D Program "Precision Medicine Research" (2017YFC0907202), Gansu Provincial Administration of Traditional Chinese Medicine (subject number GZK-2019-33), and Natural Science Foundation Project of Gansu Province (project no. 22JR5RA589).

语种：英文

外文关键词：COPD; animal models; modelling method; review-systematic; smoke plus LPS

摘要：Objective Experimental animal models have been used for decades to study the development and progression of chronic obstructive pulmonary disease (COPD). However, there is a lack of methods for constructing animal models of COPD for optimal modelling. This systematic literature review (SLR) aimed to assess the various methods used to establish COPD animal models, highlight their advantages and limitations, and explore more optimized approaches for establishing such models. Methods A systematic search was performed in four English databases (PubMed, Embase, Web of Science, and the Cochrane Library) and four Chinese databases (Chinese Biomedical Literature Database, China National Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang Database). Of the 8,015 retrieved full-text manuscripts, 453 were selected. Results Smoking (n = 140), smoking combined with lipopolysaccharide (LPS) (n = 275), smoking combined with protease drip (PPE) (n = 10), smoking combined with bacteria (n = 23), and smoking combined with particulate matter (PM2.5) (n = 5) were the most used methods for establishing animal models of COPD. Rats and mice were the most frequently selected experimental animals, with male animals accounting for 79.47% of the total. A total of 92.49 and 29.14% of the articles reviewed considered lung pathology of experimental animals only and lung pathology and lung function tests, respectively. Conclusion Our review suggests that the best way to establish an animal model of COPD is to combine smoking with LPS. Although findings from animal models of COPD cannot be directly extrapolated to human COPD, they could provide useful tools for further investigation into human COPD disease. Systematic review registration https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023407555, Identifier PROSPERO CRD42023407555.