详细信息
脓毒症严重程度与降钙素原浓度的定量关系研究 被引量:8
Clinical quantitative correlation between serum procalcitonin level and the severity of sepsis
文献类型:期刊文献
中文题名:脓毒症严重程度与降钙素原浓度的定量关系研究
英文题名:Clinical quantitative correlation between serum procalcitonin level and the severity of sepsis
作者:刘杜姣[1];黄超[2];刘东[3];薛庆亮[1]
第一作者:刘杜姣
机构:[1]兰州军区兰州总医院呼吸内科,甘肃兰州730000;[2]甘肃中医学院中西医结合系,甘肃兰州730000;[3]兰州军区兰州总医院ICU,甘肃兰州730000
第一机构:兰州军区兰州总医院呼吸内科,甘肃兰州730000
年份:2013
卷号:33
期号:9
起止页码:769
中文期刊名:中国急救医学
外文期刊名:Chinese Journal of Critical Care Medicine
收录:CSTPCD;;北大核心:【北大核心2011】;CSCD:【CSCD2013_2014】;
基金:全军十二五后勤科研面上项目(CWS11J230)
语种:中文
中文关键词:脓毒症;降钙素原;严重程度;量化关系;Logistic回归模型
外文关键词:Sepsis ; Procalcitonin; Severity; Quantitative relation; Logistic regressionmodel
摘要:目的 探讨降钙素原(PCT)浓度与脓毒症患者病情严重程度的量化关系,为临床提供脓毒症诊断和预后判断依据.方法 在这项前瞻性队列研究中,将所有于2012-11~2013-07入住兰州军区兰州总医院ICU病房、急诊科病房、呼吸内科ICU病房的脓毒症患者按病情程度分成脓毒症组、严重脓毒症组和感染性休克组,在入院当天分别检测每例入选患者血清PCT浓度、CRP浓度并进行APACHEⅡ评分.结果 总共纳入156例合格的研究对象,平均年龄(53.28±17.180)岁,28 d内病死率为25.64%.脓毒症组、严重脓毒症组和感染性休克组生存患者PCT浓度比较差异无统计学意义(P〉0.05),而三组死亡患者PCT浓度比较差异有统计学意义(P〈0.05).脓毒症生存组和死亡组PCT浓度比较差异无统计学意义(P〉0.05),严重脓毒症组、感染性休克生存组和死亡组PCT浓度比较差异有统计学意义(P〈0.05).结论 血清PCT能对严重脓毒症和感染性休克患者的预后做出评估,但尚不能对轻度脓毒症的预后带来帮助,而是可以联合IL-6等其他生化指标对其进行病情预后的评估.
Objective The aim of this study was to investigate the significance of quantitative detection of serum procalcitonin (PCT) as an early biomarker in sepsis patients, based on which to improve clinical diagnosis and prognosis of sepsis. Methods In this prospective cohort study, we selected all the sepsis patients from the ICU in the General Hospital of PLA of Lanzhou, emergency department (ED), ICU in respiratory medicine department from Nov. 2012 to July 2013. Serum PCT level and CRP level were tested and APACHE II score was recorded on the admission day. Results A total of 156 consecutive systemic inflammatory response syndrome (SIRS) patients were included: 62 with sepsis, 51 with severe sepsis, 43 with septic shock. The mean age was (53.28 ~ 17.18 )years and the mortality within 28 days was 25.64%. Serum PCT level in non - survivors but not in survivors from the sepsis group, severe sepsis group and septic shock group showed a significant difference (P 〈 0. 05) ; serum PCT level between survivors and non - survivors in sepsis group was not significantly different, but PCT between survivors and non - survivors in severe sepsis group and septic shock group were significantly different (P 〈 0.05 ). Conclusion PCT could be used to assess the prognosis of severe sepsis and septic shock patients but not mild sepsis.
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