文献类型：期刊文献

中文题名：益气活血通便颗粒成型工艺研究

英文题名：Optimization of the molding process of Yiqi Huoxue Tongbian granules

作者：权起元[1];陈飞[1];王本欢[1];杨晓玲[1];杨秀娟[1];王智勇[4];李硕[1,2,3]

第一作者：权起元

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃省高校中(藏)药化学与质量研究省级重点实验室,兰州730000;[3]甘肃省中药质量与标准研究重点实验室培育基地,兰州730000;[4]甘肃省中药现代制药工程研究院有限公司,兰州730000

第一机构：甘肃中医药大学

年份：2023

卷号：21

期号：2

起止页码：363

中文期刊名：中南药学

外文期刊名：Central South Pharmacy

收录：CSTPCD

基金：国家自然科学基金项目(No.81960713,No.82160750,No.82160755);甘肃省高等学校创新基金项目(No.2021A-079);甘肃省科技厅项目(自然科学基金No.18JR3RA201,基础研究创新群体No.21JR7RA569,青年科技基金No.20JR10RA331)。

语种：中文

中文关键词：益气活血通便颗粒;响应面法;辅料;成型工艺

外文关键词：Yiqi Huoxue Tongbian granule;response surface method;excipient;molding process

摘要：目的 优化益气活血通便颗粒的成型工艺。方法 在单因素试验的基础上,以乙醇体积分数、辅料配比(糊精∶可溶性淀粉)、辅料与浸膏用量比例为考察对象,以吸湿率、成型率、溶化时间、休止角作为考察指标,运用星点设计-响应面法结合CRITIC法计算综合评分,优选益气活血通便颗粒的成型工艺。结果 益气活血通便颗粒最优成型工艺为:乙醇体积分数50.74%、辅料配比(糊精∶可溶性淀粉=5.21∶1)、辅料与浸膏用量比例(辅料∶浸膏=3.07∶1),综合评分为77.56。结论 本法所建模型预测准确,且重复性较好,所制颗粒质量稳定可靠,可为益气活血通便颗粒生产制备提供参考。
Objective To optimize the molding process of Yiqi Huoxue Tongbian granules. Methods On the basis of the one-factor experiment, the ethanol volume fraction, excipient ratio(dextrin: soluble starch) and the ratio of excipients and extract dosage of Yiqi Huoxue Tongbian granules were measured.The moisture absorption rate, molding rate, dissolution time, and rest angle were used as the indicators.The comprehensive score was calculated by combining the star-response surface method with the CRITIC method to optimize the molding process of Yiqi Huoxue Tongbian granules. Results The optimal molding process of Yiqi Huoxue Tongbian granules was as follows: ethanol volume fraction 50.74%, excipient ratio(dextrin ∶ soluble starch = 5.21∶1), excipient and extract dosage ratio(excipient ∶ extract = 3.07∶1), and the comprehensive score was 77.56. Conclusion The method has accurate prediction, good reproducibility. The particles are stable and reliable, which can provide a reference for the production and preparation of Yiqi Huoxue Tongbian granules.