文献类型：期刊文献

中文题名：基于原发性肾病综合征中西医临床病症特点的动物模型分析

英文题名：Analysis of animal models based on characteristics of clinical symptoms of traditional Chinese and Western medicine of primary nephrotic syndrome

作者：刘灿[1];沈稼轩[2];戴恩来[1,3];丁照然[1];段淑文[1];王晓辉[1]

第一作者：刘灿

机构：[1]甘肃中医药大学中西医结合学院,甘肃兰州730030;[2]甘肃中医药大学中医临床学院,甘肃兰州730030;[3]甘肃中医药大学附属医院肾病科,甘肃兰州730030

第一机构：甘肃中医药大学中西医结合学院

年份：2023

卷号：39

期号：18

起止页码：2703

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金资助项目(8216140859);甘肃省研究生“创新之星”基金资助项目(2023CXZX-738)。

语种：中文

中文关键词：原发性肾病综合征;动物模型;临床病症特点;中西医

外文关键词：primary nephrotic syndrome;animal model;clinical symptoms;traditional Chinese and Western medicine

摘要：本文基于原发性肾病综合征的中西医临床病症特点,参照临床诊断标准,对现有的肾病综合征动物模型进行探讨,并对动物模型与临床症状的吻合度进行评价,发现已有动物模型均以明显蛋白尿、血清蛋白降低、高血脂或肾功能异常、肾组织病理改变等为主要标准,与初步临床诊断和病理组织学检查结果诊断标准基本相符。且现有病证结合动物模型中医证候的模拟因素大致符合临床证候的发病因素,能较好模拟病证结合动物模型的中医证候,但存在“病”“证”分离及证候类型过少等问题。因此希望未来聚焦完善病证结合动物模型,继续为原发性肾病综合征机制探索和新药评价添砖加瓦。
Based on characteristics of clinical symptoms of traditional Chinese and Western medicine and clinical diagnostic criteria of primary nephrotic syndrome(PNS),the available animal models were discussed,and the anastomosis between them was evaluated in this research.It was found that the animal models mainly had obvious albuminuria,hypoproteinemia,hyperlipidemia or abnormal renal function,and changes in renal histopathological,which were basically consistence in criteria of preliminary clinical diagnosis and histopathological examination.In addition,the simulating factors of combined animal models is roughly in line with pathogenic factors of clinical syndromes,which can better simulate combined models.However,there exists problems such as separation of"disease"and"syndrome",and few types of combined models.Therefore,it's hoped that we will focus on making more combined animal models to meet criteria,then continue to make contribution for the exploration of mechanism and evaluation of new medicine of PNS in future.